Results 121 to 130 of about 384,748 (295)

Yukawa Coupling Unification in SO(10) Supersymmetric Grand Unified Theories

open access: yes
We report on a preferred region of supersymmetric parameter space by t, b, tau Yukawa unification. We find a narrow region survives for mu > 0 (suggested by b --> s gamma and the anomalous magnetic moment of the muon) with A_0 \sim - 2 m_{16}, m_{16 ...
Dermisek, R.
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Special Grand Unification

open access: yes
We discuss new-type grand unified theories based on grand unified groups broken to their special subgroups as well as their regular subgroups. In the framework, when we construct four-dimensional (4D) chiral gauge theories, i.e., the Standard Model (SM),
Yamatsu, Naoki
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

İbn Sînâ ve Tûsî’ye Göre Tanrı’nın Bilgisi

open access: yesEskiyeni, 2016
Tanrı’nın bilgisi, Müslüman filozoflar tarafından bilgi teorisinin konusu olarak değil, metafizik kapsamında bir mesele olarak ele alınmıştır. İslam felsefesinde hususi bir epistemoloji başlığı açılmış olmamakla birlikte insanın bilmesi ve idraki hem ...
Murat Demirkol
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Unification

open access: yes, 2015
This publication is comprised of two equations which are derived and extrapolated from a book that I created in 2015/2016: Probability, Quantum Mechanics, and Probability-Quanta. The latter consists of various thought experiments and postulates. I have included scans from the original book in an effort to demonstrate my work and in the hopes of ...
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Towards the Non-Chiral Extension of SM and MSSM

open access: yes
We show that in some SU(N) type GUTs with the complementary pairs of the conjugated fermion multiplets there naturally appear the relatively light ($M\ll M_{GUT}$) vectorlike fermions which considerably modify the desert physics.
A.B. Kobakhidze   +27 more
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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