Results 111 to 120 of about 384,748 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On Unification Modulo One-Sided Distributivity: Algorithms, Variants and Asymmetry

An algorithm for unification modulo one-sided distributivity is an early result by Tid\'en and Arnborg. More recently this theory has been of interest in cryptographic protocol analysis due to the fact that many cryptographic operators satisfy this ...
Marshall, Andrew M, Meadows, Catherine, Narendran, Paliath   +2 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Gauge Coupling Unification due to Non-universal Soft Supersymmetry Breaking

Gauge coupling unification is studied in the MSSM with non-universal soft supersymmetry breaking terms. If gaugino masses are sufficiently smaller than scalar soft masses and the scalar soft masses have also certain types of non-universality, gauge ...
Amaldi, Antoniadis, Antoniadis, Cvetič, Daijiro Suematsu, de Carlos, de Carlos, de la Macorra, Derendinger, Derendinger, Dixon, Ellis, Ferrara, Ferrara, Ferrara, Font, Ginsparg, Green, Hisano, Ibáñez, Ibáñez, Ibáñez, Kaplunovsky, Kaplunovsky, Kikkawa, Langacker, Sakai, Tatsuo Kobayashi, Yoshio Yamagishi   +28 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Synthesis through Unification

Given a specification and a set of candidate programs (program space), the program synthesis problem is to find a candidate program that satisfies the specification.
Alur, Rajeev, Cerny, Pavol, Radhakrishna, Arjun   +2 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

b-tau Unification and neutrino masses in SU(5) extensions of the MSSM with radiative electroweak symmetry breaking

We make a complete analysis of the Yukawa coupling unification in SU(5) extensions of the MSSM in the framework of the radiative symmetry breaking scenario.
A. B. Lahanas, A. Brignole, A. Dedes, A. Dedes, A. Dedes, A. Donini, A. Faraggi, A. Masiero, B. Grinstein, C. Bachas, C. Kounnas, F. Vissani, G. G. Ross, G. Gamberini, G. K. Leontaris, H. Murayama, H. P. Nilles, J. Bagger, J. Ellis, J. Ellis, J. Ellis, J. Hisano, J. L. Lopez, K. Inoue, K. Tamvakis, L. Alvarez-Gaumé, L. E. Ibañez, L. E. Ibañez, L. E. Ibañez, M. Carena, M. Gell-Mann, N. Polonsky, N. Sakai, P. Chankowski, P. Langacker, P. Nath, R. Arnowitt, R. M. Barnett, R. Peccei, R. Peccei, R. Rattazzi, S. Dimopoulos, T. Yanagida   +42 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source