Results 61 to 70 of about 51,133 (290)

Three-Dimensional Time and One-Dimensional Space: A Basic Reformulation of Physical Reality

Reports in Advances of Physical Sciences
This paper proposes a radical reformulation of spacetime structure, positing that reality consists basically of one spatial dimension and three temporal dimensions, with our perceived three-dimensional space evolving as a projection from this underlying ...
Gunther Kletetschka
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

On the Invariant and Geometric Structure of the Holomorphic Unified Field Theory

Axioms
We present the invariant structure of a Holomorphic Unified Field Theory in which gravity and gauge interactions arise from a single geometric framework.
John W. Moffat, Ethan James Thompson
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Lagrangian-Hamiltonian unified formalism for field theory [PDF]

, 2004
The RuskSkinner formalism was developed in order to give a geometrical unified formalism for describing mechanical systems. It incorporates all the characteristics of Lagrangian and Hamiltonian descriptions of these systems (including dynamical equations
Echeverría Enríquez, Arturo, Narciso Román-Roy, Jesús Marı́n-Solano, López, Carlos, Carlos López, Miguel C. Muñoz-Lecanda, Muñoz Lecanda, Miguel Carlos, Arturo Echeverrı́a-Enrı́quez, Román-Roy, Narciso, Marín Solano, Jesús   +9 more
core   +1 more source

Solitons in 4d Wess-Zumino-Witten models -- Towards unification of integrable systems -- [PDF]

Open Communications in Nonlinear Mathematical Physics
We construct soliton solutions of the four-dimensional Wess-Zumino-Witten (4dWZW) model in the context of a unified theory of integrable systems with relation to the 4d/6d Chern-Simons theory.
Masashi Hamanaka, Shan-Chi Huang
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Unified Phase Field Theory (UFT): A Unified Field Theory of Fundamental Interactions [PDF]

Unified Phase Field Theory (UFT) is proposed as a unified field theory in which a single phase field constitutes the fundamental physical entity. Within this framework, spacetime geometry, gauge interactions, and matter arise as effective manifestations ...
Sepiashvili, David
core   +1 more source

Towards a Unified Theory of Health-Disease: I. Health as a complex model-object

Revista de Saúde Pública, 2013
Theory building is one of the most crucial challenges faced by basic, clinical and population research, which form the scientific foundations of health practices in contemporary societies.
Naomar Almeida-Filho
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source