Results 141 to 150 of about 28,605,013 (311)
, 2006 208 p.The Health Systems in Transition (HiT) series provide detailed descriptions of health systems in the countries of the WHO European Region as well as some additional OECD countries.
van Waveren, Michelle +5 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
O Pacto pela Saúde e o processo de regionalização no estado de Mato Grosso
Saúde em DebateA regionalização da saúde no estado de Mato Grosso iniciou-se nos anos 1990. Neste trabalho, analisou-se a atuação da Secretaria de Estado de Saúde, no período de 2006 a 2011, mediante as dimensões: institucionalidade, governança e impactos da ...
Nereide Lúcia Martinelli +2 more
doaj +1 more source
Confronting social and health inequalities in the access to Unified Health System
Brazilian Journal of Health ReviewObjetivo: Discutir a relação entre a estrutura social, econômica e de identidade do Brasil e a necessidade de manter o Sistema Único de Saúde como uma política pública mais equitativa. Métodos: Foi realizada uma pesquisa bibliográfica nas bases de dados MEDLINE, via Pubmed, SciELO e BVS, com os descritores: fatores socioeconômicos, Sistema Único de ...
Caio Vieira de Barros Arato +6 more
openaire +1 more source
xii, 56 p.Increasing migration flows and recent displacement crises in Europe have placed new demands on national health systems, particularly in countries transitioning to refugee-hosting contexts such as Lithuania.
World Health Organization
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Deepwater Horizon Response: Gulf of Mexico Oil Spill Response
, 2010 This website served as the focal point for the Deepwater Horizon Unified Command, a group of organizations that had involvement with the British Petroleum (BP) explosion and oil spill that occurred in the Gulf of Mexico in April 2010.
Deepwater Horizon Unified Command
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source