Results 171 to 180 of about 128,740 (303)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Epidemiological profile and temporal trend of hospitalizations for Alzheimer's disease in the Brazilian Unified Health System (2012-2022). [PDF]

Arq Neuropsiquiatr
Bertella E, Correa FAA, Iop RDR, Nazario NO, Silva FCD, Belmonte LM.   +5 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Financial sustainability and the incorporation of technologies in the Brazilian Unified Health System: advances, challenges, and perspectives. [PDF]

Sao Paulo Med J
Faria GF, Pêgo-Fernandes PM.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

WHERE ARE THE ORTHOPEDIC ONCOLOGY CENTERS IN THE BRAZILIAN UNIFIED HEALTH SYSTEM (SUS)? [PDF]

Acta Ortop Bras
Gonçalves GM, de Souza DA, Engel EE.
europepmc   +1 more source

PET-HEALTH AS A GUIDE FOR THE TRAINING IN NURSING FOR THE UNIFIED HEALTH SYSTEM

, 2019
Luiz Roberto Augusto Noro, José Luís Medina Moya   +1 more
openalex   +1 more source

The court and the delivery of medecines by unified health system in Brazil : recent developments in a difficult relationship between judges and policy-makers [PDF]

, 2018
Eduardo Rocha Dias, Gina Vidal Marcílio Pompeu   +1 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Teaching-service-community integration, active methodologies and Unified Health System: perceptions of Dentistry students

, 2019
Alessandro Diogo De‐Carli, Államy Danilo Moura e Silva, Edílson José Zafalon, Sandra Minardi Mitre, Paulo Zárate Pereira, Rafael Aiello Bomfim, Leila Simone Foerster Merey, Melina Raquel Theobald   +7 more
openalex   +1 more source