Results 171 to 180 of about 2,337,724 (336)
The economic and demographic transition, mortality, and comparative development [PDF]
, 2012 We propose a unified growth theory to investigate the mechanics generating the economic and demographic transition, and the role of mortality differences for comparative development.
Cervellati , Matteo, Sunde, Uwe
core +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A study of existing Ontologies in the IoT-domain [PDF]
, 2017 Several domains have adopted the increasing use of IoT-based devices to collect sensor data for generating abstractions and perceptions of the real world. This sensor data is multi-modal and heterogeneous in nature.
Agarwal, Rachit +4 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A crise mundial de 2008 e o golpe do capital na política de saúde no Brasil
Saúde em DebateRESUMO O objetivo do artigo foi analisar a conjuntura posterior às eleições presidenciais de 2014, discutindo possíveis relações com a crise econômica mundial e com os desdobramentos do golpe de 2016 na saúde.
Carmen Fontes de Souza Teixeira +1 more
doaj +1 more source
Learning to Address Health Inequality in the United States with a Bayesian Decision Network
, 2018 Life-expectancy is a complex outcome driven by genetic, socio-demographic, environmental and geographic factors. Increasing socio-economic and health disparities in the United States are propagating the longevity-gap, making it a cause for concern ...
Chugh, Samarth +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Saúde em DebateO artigo trata das formas de fazer a regionalização da saúde, objetivando analisar as dimensões da institucionalidade e governança na sua gestão. Fez-se pesquisa qualitativa retrospectiva em base documental (1995-2009).
Ruth Terezinha Kehrig +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Building the Science Foundation of a Modern Food Safety System: Lessons From Denmark, the Netherlands, and the United Kingdom on Creating a More Coordinated and Integrated Approach to Food Safety Information [PDF]
, 2010 Examines how food safety reforms in three countries and the European Union affected data collection and analysis, coordination and integrated approaches, and use of data for prevention. Makes recommendations for U.S.
core