Results 91 to 100 of about 4,004,008 (323)

Uniform bounds for equivariant homotopies

Topology and its Applications, 1989
Sei M kompakte Riemannsche Mannigfaltigkeit und \(\pi_ 1(M)\) endlich. Die Breite \(| H|\) einer Homotopie H: \(X\times I\to M\) ist das Spektrum der Längen aller Deformationswege. Zusammen mit Calder bewiesen Verff. in früheren Arbeiten folgendes Theorem: Für alle n gibt es eine reelle Zahl \(B_ n(M)\), so daß alle Homotopien H mit Dim(X)\(\leq n\) in
Siegel, Jerrold, Williams, Frank
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Randi´c Matrix and Randi´c Energy of Uniform Hypergraphs [PDF]

Mathematics Interdisciplinary Research
‎The Randi´c matrix $R=[r_{ij}]$ of a graph $ G=(V,E) $ was defined as $r_{ij}=\frac{1}{\sqrt{d_id_j}}$ if vertices $v_i$ and $v_j$ are adjacent and $r_{ij}=0$ otherwise‎, ‎where $d_i$ is the degree of the vertex $v_i\in V$‎.
Gholam Hassan Shirdel, Ameneh Mortezaee, Laith Alaameri   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A general result on the spectral radii of nonnegative k-uniform tensors

AIMS Mathematics, 2020
In this paper, we define $k$-uniform tensors for $k\geq 2$, which are more closely related to the $k$-uniform hypergraphs than the general tensors, and introduce the parameter $r^{(q)}_{i}(\mathbb{A})$ for a tensor $\mathbb{A}$, which is the ...
Chuang Lv, Lihua You, Yufei Huang
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Regulating Constraint-Following Bound for Uncertain Mechanical Systems: An Indirect Control Approach

IEEE Access, 2020
This paper proposes an indirect approach of constraint-following control for mechanical systems with (possibly fast) time-varying uncertainty. It proposes to design controller for the system to render bounded constraint-following error.
Qinqin Sun, Guolai Yang, Xiuye Wang, Ye-Hwa Chen   +3 more
doaj   +1 more source

Quasimodes and a lower bound on the uniform energy decay rate for Kerr–AdS spacetimes [PDF]

, 2013
We construct quasimodes for the Klein-Gordon equation on the black hole exterior of Kerr-Anti-de Sitter (Kerr-AdS) spacetimes. Such quasi-modes are associated with time-periodic approximate solutions of the Klein Gordon equation and provide natural ...
G. Holzegel, Jacques Smulevici
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source