Results 71 to 80 of about 1,481,194 (295)

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

On Various Modes of Convergence and Notions of Exhaustiveness With Korovkin-Type Theorems

Journal of Mathematics
In this paper, we introduce refined notions related to convergence and exhaustiveness for sequences of functions defined between metric spaces. These include rigid uniform alpha convergence as a strengthened variant of alpha convergence, along with ...
Alper Erdem, Tuncay Tunç
doaj   +1 more source

Fitted mesh numerical method for two-parameter singularly perturbed partial differential equations with large time lag

Partial Differential Equations in Applied Mathematics
In this study, we devise a parameter-uniform second-order numerical method for two-parameter singularly perturbed partial differential equations with large time lag.
Fasika Wondimu Gelu, Imiru Takele Daba, Wondwosen Gebeyaw Melesse, Guta Demisu Kebede   +3 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Convergence of the Difference Solutions of a Dirichlet Problem With a Discontinuous Derivative of the Boundary Function for a Singularly Perturbed Convection-Diffusion Equation

Моделирование и анализ информационных систем, 2016
We consider a Dirichlet problem for a singularly perturbed convection-diffusion equation with constant coefficients in a rectangular domain in the case when the convection is parallel to the horizontal faces of the rectangular and directed to the right ...
T. Ya. Ershova
doaj   +1 more source

Uniform convergence guarantees for the deep Ritz method for nonlinear problems. [PDF]

Adv Contin Discret Model, 2022
Dondl P, Müller J, Zeinhofer M.
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Uniform convergence on classes of subsets [PDF]

In the study of uniform convergence, one is led naturally to the question of how uniform convergence on subsets relates to uniform convergence on the whole space. This paper develops theorems on how pointwise convergence relates to uniform convergence on
Shiflett, Ray Calvin
core   +3 more sources

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source