Results 41 to 50 of about 5,706,833 (248)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Hybrid Ensemble-Based QoE Prediction From QoS and User Satisfaction Data: A Case Study on Cameroon’s 3G/4G Mobile Networks

IEEE Access
The rapid growth of mobile internet and social media usage in Sub-Saharan Africa has amplified the need for accurate Quality of Experience (QoE) assessment in resource-constrained network environments.
Kinge Mbeke Theophane Osee, Valery Nkemeni, Michael Ekonde Sone, Godlove Suila Kuaban   +3 more
doaj   +1 more source

Spatial analysis of urban violence based on emergency room data Análisis espacial de la violencia urbana basada en datos de centros de urgencia Análise espacial da violência urbana baseada em dados de pronto-socorro

Revista de Saúde Pública, 2008
OBJECTIVE: To estimate the spatial intensity of urban violence events using wavelet-based methods and emergency room data. METHODS: Information on victims attended at the emergency room of a public hospital in the city of São Paulo, Southeastern Brazil ...
Liliam Pereira de Lima, Julio da Motta Singer, Paulo Hilário do Nascimento Saldiva   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Metodologías para el diseño de ontologías Web = Web ontologies design methodologies

Información, Cultura y Sociedad, 2018
El artículo analiza las características de las ontologías Web, junto con su definición, su constitución y las tecnologías que se adoptan para su diseño e implementación en el marco de la Web Semántica.
Elsa E. Barber, Silvia Pisano, Sandra Romagnoli, Gabriela de Pedro, Carolina Gregui, Nancy Blanco, María Rosa Mostaccio   +6 more
doaj  

Climate-driven morphological change in mosquito vectors: implications for vector competence, distribution and disease transmission—a systematic review

Frontiers in Veterinary Science
BackgroundClimate change is altering the thermal environments experienced by mosquito vectors during development, with consequences for adult morphology and potentially for vector competence and pathogen transmission dynamics.AimThis systematic review ...
Uzochukwu G. Ekeleme, Ugonma Winnie Dozie, Juliana C. Omire, Ezejindu Cosmas Nnadozie, Onuigbo Martin Chinemerem, Chimezie Christian Iwuala, Nwokeleme Ogechi Chikaodi, Christopher Chike A. Okereke, Uchechukwu M. Chukwuocha   +8 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Interest groups in Lithuania: dynamics of development and characteristics of institutionalization

Politologija, 2000
The problems that are pertinent to the activities of the interest groups, their relationship with the State, etc., are obviously understudied in Lithuania.
Alvidas Lukošaitis
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source