Results 51 to 60 of about 25,877 (257)

Cyber Threat Intelligence Exchange [PDF]

, 2020
The processing and exchange of Cyber Threat Intelligence (CTI) has become an increas- ingly important topic in recent years. This trend can be attributed to various factors.
Menges, Florian
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Realist review: Current practice and future prospects [PDF]

, 2016
Realist review has emerged as a specific literature review approach that is concerned with explaining the outcomes of complex intervention programs. We undertook a systematic scoping review to examine the current practice of realist
Nanavati, Julie, Berg, Rigmor C., Berg, Rigmor   +2 more
core   +1 more source

Robotisation of the national economy: Social effects

Journal of New Economy
The relevance of the study on the social consequences of large-scale robotisation in Russia, as envisaged by the federal initiative “Development of industrial robotics and production automation”, stems from the contradiction between the necessity of ...
Evgeny V. Balatsky, Natalia A. Ekimova
doaj   +1 more source

RF-SVR-based prediction methodology for metal tube-bending rebound: Handling non-uniformity and limited sample challenges

PLOS One
This paper explores a prediction algorithm for determining the rebound angle of non-uniform and small-sample tubes. To address the issues of non-uniform and small-sample data, this paper proposes an algorithm based on Random Forest-Support Vector Regression (RF-SVR).
Ziluo Fang, Pengfei Zhang, Liangyou Li, Qingzhu Zhang   +3 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Methodological model for curricular design in HIV / AIDS prevention for uniformed personnel of the Colombian Military Forces [PDF]

, 2014
La presente investigación tiene como objetivo construir una metodología estandarizada que sirva como modelo para el diseño de currículos de prevención y control del VIH/SIDA para las Escuelas de Formación y Capacitación de las Fuerzas Militares de ...
Meneses Posada, María Juliana
core  

Big data and urban system model - Substitutes or complements? A case study of modelling commuting patterns in Beijing [PDF]

, 2018
The emergence of urban big data is transforming the existing research paradigms in urban studies. New theories and analytical methods are required to meet the methodological challenges.
Mingrui Mao, Li Wan, Shuo Gao, Lei Yang, Chen Wu, Ying Jin   +5 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source