Results 71 to 80 of about 5,558,106 (237)

Benchmarking the negatives: Effect of negative data generation on the classification of miRNA-mRNA interactions.

PLoS Computational Biology
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In animals, this regulation is achieved via base-pairing with partially complementary sequences on mainly 3' UTR region of messenger RNAs (mRNAs ...
Efrat Cohen-Davidi, Isana Veksler-Lublinsky   +1 more
doaj   +1 more source

De-Escalation of Broad-Spectrum and Last-Resort Antibiotics in Critically Ill Adults with Gram-Negative Infections: A Scoping Review and Evidence-Informed Framework for Tertiary-Care ICUs

Antibiotics
Background: Early broad-spectrum empirical therapy is life-saving in critical illness, but its unnecessary continuation drives resistance, toxicity, and cost; antibiotic de-escalation is the principal stewardship strategy for resolving this tension, yet ...
Mihai Sava, Ioana Roxana Codru, Alina Simona Bereanu, Anca Maria Frățilă, Bogdan Ioan Vintilă   +4 more
doaj   +1 more source

Base-Identity and Uniform Exponence: Alternatives to Cyclicity

, 1995
This paper proposes to reinterpret cyclic effects not as input-output relations between separate levels (McCarthy & Prince 1993, Kenstowicz 1994) but rather--building on the proposals of Kraska (1995)—as similarity constraints between and among ...
Michael, Kenstowicz
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Implementing Scientific and Technological Territorial Potential Through Interregional Integration Based on the “Smart” Specialization Approach

Управленческое консультирование
Relevance and objectives of the research. Regional scientific and technological potential can be revealed and fully realized only taking into account the possibilities of interregional partnership and cooperation and provided that the priorities of ...
L. A. Gamidullayeva
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Comparison of Different Methodological Approaches to Simulate Geo-Referenced Populations to Be Used in a Cluster Analysis of Childhood Leukaemia Cases in Germany

Epidemiology, Biostatistics and Public Health
Introduction A key methodological challenge in epidemiological studies using a cluster analysis approach is the choice of an appropriate set of controls.
Rossana Di Staso , Emilio Gianicolo
doaj   +1 more source

Uniform jury instructions. Civil

, 1993
This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government ...

core