Results 71 to 80 of about 25,877 (257)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Benchmarking the negatives: Effect of negative data generation on the classification of miRNA-mRNA interactions.

PLoS Computational Biology
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In animals, this regulation is achieved via base-pairing with partially complementary sequences on mainly 3' UTR region of messenger RNAs (mRNAs ...
Efrat Cohen-Davidi, Isana Veksler-Lublinsky   +1 more
doaj   +1 more source

Comparison of Different Methodological Approaches to Simulate Geo-Referenced Populations to Be Used in a Cluster Analysis of Childhood Leukaemia Cases in Germany

Epidemiology, Biostatistics and Public Health
Introduction A key methodological challenge in epidemiological studies using a cluster analysis approach is the choice of an appropriate set of controls.
Rossana Di Staso , Emilio Gianicolo
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Methodological approaches to analyzing cash funds of enterprises [PDF]

Провадження господарської діяльності без залучення грошових коштів не уявляється можливим, адже гроші беруть безпосередню участь у найрізноманітніших операціях підприємства, будь-то оплата орендних послуг чи виплата заробітної плати, забезпечення суб ...
Бобирь, Ольга Іванівна, Bondarenko, Natalya, Bobyr, Olga, Бондаренко, Наталія Миколаївна   +3 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Tax Policy and Employment: How Does the Swedish System Fare? [PDF]

This paper reviews the literature on optimal taxation of labour income and the empirical work on labour supply and the elasticity of taxable income in Sweden.
Hakan Selin, Jukka Pirttilä
core   +3 more sources

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Methodological guide for the constitution and operation of a sports club of handball [PDF]

, 2017
El objeto de este artículo es poder guiar a las personas que deseen constituir un club deportivo, describiendo en este trabajo, el valor formativo que los clubes deportivos tienen, el uso adecuado del tiempo libre y el ocio en los niños y en la juventud.
Galindo Rojas, Édgar Felipe
core   +1 more source

Vasopressin as a hemostatic agent in laparoscopic myomectomy: a systematic review and meta-analysis of efficacy, safety and clinical outcomes

Middle East Fertility Society Journal
Introduction Hemorrhage represents a significant complication during laparoscopic myomectomy, with transfusion requirements occurring in 5–40% of procedures.
Atul Kumar Singh, Yashpal Singh, Sanjeev Kumar, Amrita Rath, Amit Kumar Nayak, Abhinay Jayanthi   +5 more
doaj   +1 more source