Results 71 to 80 of about 41,835 (261)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

UTLIZATION OF UNIFORMITY TRIALS TO ESTIMATE THE OPTIMUM PLOT SIZE AND SHAPE AND THE NUMBER OF REPLICATIONS IN MAIZE YIELD TRIALS [PDF]

Egyptian Journal of Agricultural Sciences, 2013
W. Fares, H. Fateh, Sh. Shaboon
doaj   +1 more source

Outcome measures in vitiligo: A narrative review

Pigment International
Vitiligo disease course being unpredictable in course, it is often difficult to monitor the response to therapy. Though there are many outcome measures, there is a lack of uniformity in reporting these across research papers and clinical trials making it
K.B. Meghana, Anuradha Bishnoi, Davinder Parsad   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Eligibility and Endpoints for Clinical Trials in Trimodality Therapy for Bladder Cancer

Bladder Cancer
BACKGROUND: Trimodality therapy (TMT) is a viable option for muscle-invasive localized bladder cancer, providing an alternative to radical cystectomy in properly selected patients.
Parminder Singh, Leslie Ballas, Guru P. Sonpavde, Ronald C. Chen, Rick Bangs, Brian C. Bauman, Himanshu Nagar, Scott E. Delacroix, Seth P. Lerner, Jason A. Efstathiou   +9 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Integrated analysis of key parameters in the design of a gravity-fed subsurface drip irrigation system under low pressure for predominantly sandy soil

Agricultural Water Management
Gravity-fed subsurface drip irrigation (GSDI) supplies water directly to the root zone without the need for pumping, which makes it particularly suitable for areas with limited energy access.
Eric Kakanda Tshitende, Pierre M. Kabuya, Paul Malumba, Joost Wellens   +3 more
doaj   +1 more source

Plot size and number of replicates in times of sowing and cuts of millet

Revista Brasileira de Engenharia Agrícola e Ambiental, 2016
The objective of this study was to determine the optimum plot size (Xo) and number of replicates to evaluate millet shoot fresh matter in times of sowing and cuts.
Cláudia Burin, Alberto Cargnelutti Filho, Bruna M. Alves, Marcos Toebe, Jéssica A. Kleinpaul   +4 more
doaj   +1 more source

Uniformity trials simulation to determine the statistical power in yield rice trials

, 2021
Introduction. Prospective analysis of the statistical power of a hypothesis test should be one of the most important stages in any experiment, however, it is frequently omitted. In Costa Rica, within the literature consulted, no research related to this topic was found for yield experiments in rice cultivation. Objective. To simulate ...
openaire   +1 more source