Results 91 to 100 of about 14,273 (226)

Emerging Agents for Boron Neutron Capture Therapy: Biomolecular Carriers Paving the Way for Precision Radiotherapy

Precision Radiation Oncology, EarlyView.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

Formation of unilamellar dipalmitoylphosphatidylcholine vesicles promoted by Ca2+ ions: A small-angle neutron scattering study

, 2007
Dipalmitoylphosphatidylcholine (DPPC) was hydrated in 0.2-60 mM solution of CaCl 2 in heavy water and thoroughly homogenized by freezing-thawing process.
Lengyel, Adrián, Teixeira, José, Uhríková, Daniela, Almásy, László   +3 more
core  

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury

Drug Delivery, 2017
The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety.
Nan Li, Dong Weng, Shan-Mei Wang, Yuan Zhang, Shan-Shan Chen, Zhao-Fang Yin, Jiali Zhai, Judy Scoble, Charlotte C. Williams, Tao Chen, Hui Qiu, Qin Wu, Meng-Meng Zhao, Li-Qin Lu, Xavier Mulet, Hui-Ping Li   +15 more
doaj   +1 more source

Polymeric membranes with selective permeability : shielding of an antioxidant enzyme [PDF]

, 2008
In this work we designed an antioxidant nanoreactor based on the encapsulation of CuZnSOD in amphiphilic copolymer nanovesicles. The nanovesicles are formed by self-assembly of amphiphilic copolymer poly-(2-methyloxazoline)-poly- (dimethylsiloxane ...
Axthelm, Fabian
core   +1 more source

PEO-b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes.

PLoS ONE, 2019
We propose a strategy to counteract the salt-driven disassembly of multiliposomal complexes made by electrostatic co-assembly of anionic small unilamellar liposomes and cationic star-shaped polyelectrolytes (made of quaternized poly(dimethylaminoethyl ...
Camille E Pinguet, Esther Ryll, Alexander A Steinschulte, Jón M Hoffmann, Monia Brugnoni, Andrey Sybachin, Dominik Wöll, Alexander Yaroslavov, Walter Richtering, Felix A Plamper   +9 more
doaj   +1 more source

Construction of a Gene Screening System Using Giant Unilamellar Liposomes and a Fluorescence-Activated Cell Sorter

, 2016
We have constructed a gene screening system composed of an in vitro transcription–translation system encapsulated within giant unilamellar liposomes and a fluorescence-activated cell sorter (FACS), which allows high-throughput screening of genes encoding
Takeshi Sunami (2077204), Tetsuya Yomo (67503), Norikazu Ichihashi (1633534), Tomoaki Matsuura (307151), Takehiro Nishikawa (2077201)   +4 more
core   +1 more source

Delivery of membrane proteins into small and giant unilamellar vesicles by charge-mediated fusion

, 2016
One of the current challenges in synthetic biology is the production of stable membrane mimetic systems and the insertion of components in these systems.
von Ballmoos, Christoph, Olivier Biner, Christoph von Ballmoos, Müller, Yannic, Schick, Thomas, Yannic Müller, Biner, Olivier Felix, Thomas Schick   +7 more
core   +1 more source

Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]

, 2005
Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Jeremy P., Bradshaw, Jeremy, Hauss, T, Ashley, Richard H., Balali-Mood, K, Bradshaw, J. P., Balali-Mood, K., Hauß, Thomas, Ashley, R.H., Balali-Mood, Kia, Ashley, R. A., Ashley, R H, Balali Mood, K., Hau , T., Bradshaw, J.P.   +14 more
core   +1 more source

Effect of the Incorporation of Functionalized Cyclodextrins in the Liposomal Bilayer

Molecules, 2019
Liposomes loaded with drug–cyclodextrin complexes are widely used as drug delivery systems, especially for species with low aqueous solubility and stability. Investigation of the intimate interactions of macrocycles with liposomes are essential for
Romina Zappacosta, Benedetta Cornelio, Serena Pilato, Gabriella Siani, François Estour, Massimiliano Aschi, Antonella Fontana   +6 more
doaj   +1 more source