Results 71 to 80 of about 103,113 (203)

Nuclear Assembly in Giant Unilamellar Vesicles Encapsulating Xenopus Egg Extract

Small, EarlyView.
Cell nuclei have been reconstituted in membrane‐less compartments using Xenopus egg extract, but not within lipid bilayer‐enclosed compartments. This study modifies the inverted emulsion method by adding chloroform to the lipid‐dispersed oil and extending lipid monolayer formation at the oil–egg extract interface, enabling the encapsulation of egg ...
Sho Takamori, Hisatoshi Mimura, Toshihisa Osaki, Tomo Kondo, Miyuki Shintomi, Keishi Shintomi, Miho Ohsugi, Shoji Takeuchi   +7 more
wiley   +1 more source

Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury

Drug Delivery, 2017
The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety.
Nan Li, Dong Weng, Shan-Mei Wang, Yuan Zhang, Shan-Shan Chen, Zhao-Fang Yin, Jiali Zhai, Judy Scoble, Charlotte C. Williams, Tao Chen, Hui Qiu, Qin Wu, Meng-Meng Zhao, Li-Qin Lu, Xavier Mulet, Hui-Ping Li   +15 more
doaj   +1 more source

The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways

Small, EarlyView.
Lipid nanoparticles are vital for drug delivery, but their cellular interactions remain unclear. This study shows that non‐lamellar lyotropic liquid crystalline nanoparticles (LLCNPs) ‐ including cubosomes, hexosomes, and micellar cubosomes ‐ preferentially use passive pathways like membrane fusion, bypassing endocytic recycling faced by lamellar ...
Sue Lyn Yap, Brendan Dyett, Alison J. Hobro, Han Nguyen, Nicholas I. Smith, Calum J. Drummond, Charlotte E. Conn, Nhiem Tran   +7 more
wiley   +1 more source

PEO-b-PPO star-shaped polymers enhance the structural stability of electrostatically coupled liposome/polyelectrolyte complexes.

PLoS ONE, 2019
We propose a strategy to counteract the salt-driven disassembly of multiliposomal complexes made by electrostatic co-assembly of anionic small unilamellar liposomes and cationic star-shaped polyelectrolytes (made of quaternized poly(dimethylaminoethyl ...
Camille E Pinguet, Esther Ryll, Alexander A Steinschulte, Jón M Hoffmann, Monia Brugnoni, Andrey Sybachin, Dominik Wöll, Alexander Yaroslavov, Walter Richtering, Felix A Plamper   +9 more
doaj   +1 more source

Effect of the Incorporation of Functionalized Cyclodextrins in the Liposomal Bilayer

Molecules, 2019
Liposomes loaded with drug–cyclodextrin complexes are widely used as drug delivery systems, especially for species with low aqueous solubility and stability. Investigation of the intimate interactions of macrocycles with liposomes are essential for
Romina Zappacosta, Benedetta Cornelio, Serena Pilato, Gabriella Siani, François Estour, Massimiliano Aschi, Antonella Fontana   +6 more
doaj   +1 more source

Improving Vesicular Integrity and Antioxidant Activity of Novel Mixed Soy Lecithin-Based Liposomes Containing Squalene and Their Stability against UV Light

Molecules, 2020
In order to improve the membrane lipophilicity and the affinity towards the environment of lipid bilayers, squalene (SQ) could be conjugated to phospholipids in the formation of liposomes.
Sahar Pakbaten Toopkanloo, Tai Boon Tan, Faridah Abas, Mohammad Azam, Imededdine Arbi Nehdi, Chin Ping Tan   +5 more
doaj   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells

Small Science, EarlyView.
Native nuclei are isolated and incorporated into polymeric giant unilamellar vesicles (pGUVs) using microfluidics. Nucleated pGUVs retain nuclear integrity and function, providing a new platform to study the import process of peptide‐based multicompartment micelles via nuclear localization signals. This bottom‐up chimeric system lays the groundwork for
Lukas Heuberger, Arianna Balestri, Shabnam Tarvirdipour, Larisa E. Kapinos, Roderick Y. H. Lim, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +7 more
wiley   +1 more source

Effect of Fragarin on the Cytoplasmic Membrane of the Phytopathogen Clavibacter michiganensis

Molecular Plant-Microbe Interactions, 2001
Fragarin, an antibiotic that was isolated and purified from a soluble fraction of strawberry leaves, may be a new type of preformed antimicrobial compound (phytoanticipin).
M. Paula Filippone, Juan C. Diaz-Ricci, Atilio P. Castagnaro, Ricardo N. Farías   +3 more
doaj   +1 more source

Gold Nanoparticle Adsorption and Uptake are Directed by Particle Capping Agent

Small Science, EarlyView.
This study explores how ligand‐coated gold nanoparticles (NPs) interact with model membranes. Combining atomic force microscopy (AFM) and molecular dynamics (MD) simulations, it shows how coating properties affect adsorption. The AFM‐MD approach offers a predictive platform for nanoparticle design and toxicity, enabling tailored nanomedicine ...
Rashad Kariuki, Rowan Penman, Alexander D. Newbold, Kalpani A. Mirihana, Pierre H. A. Vaillant, Tilly P. Shepherd, Nastaran Meftahi, Gary Bryant, Kislon Voïtchovsky, Claudia Contini, Andrew Hung, Kevion K. Darmawan, Charlotte E. Conn, Saffron J. Bryant, Andrew J. Christofferson, Aaron Elbourne   +15 more
wiley   +1 more source