Results 81 to 90 of about 103,113 (203)
Osmotically Balanced, Large Unilamellar Liposomes for Sustained Bupivacaine Release: From the Development of Liposomes to Their in Vivo Application [PDF]
, 2021 Hyebin Yoo +3 more
openalex +1 more source
A Kinetic Model of Antigen‐Dependent IgG Oligomerization and Complement Binding
Small Science, EarlyView.A kinetic model capable of predicting IgG oligomerization, a key step in activating the classical complement pathway (CCP) of the immune system, is presented. The impacts of IgG subclass, concentration, and antigen density are analyzed using advanced biophysical techniques.
Jürgen Strasser +7 more
wiley +1 more source
FASEB BioAdvances, EarlyView.Plasmalogens are specialized lipids affecting the membrane structure, dynamics, and key cell signaling pathways. They protect cells from oxidative damage. Plasmalogen deficiency is associated with severe diseases. Lipid nanoparticles and nanomedicine offer unexplored therapeutic potential for restoring plasmalogen levels under pathological conditions ...
Yu Wu +3 more
wiley +1 more source
PI5P4K inhibitors: promising opportunities and challenges
The FEBS Journal, EarlyView.Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi +16 more
wiley +1 more source
Natural aminosterols inhibit NMDA receptors with low nanomolar potency
The FEBS Journal, EarlyView.Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani +9 more
wiley +1 more source
The FEBS Journal, EarlyView.Myelin is a multilayered proteolipid membrane in the nervous system. The lipid membranes are held together by specific proteins, and here, we studied three such proteins—P0, MBP, and P2. Our experiments show that the three proteins may act in synergy at the molecular level, while they also compete for lipid membrane surface binding.
Oda C. Krokengen +9 more
wiley +1 more source
Ultrasonic evidence for structural relaxation in large unilamellar liposomes [PDF]
, 1983 Philip R. Strom-Jensen +2 more
openalex +1 more source
Protein Science, Volume 34, Issue 6, June 2025.Abstract Mitochondrial dynamics are regulated by coordinated fission and fusion events that rely on key proteins and lipids organized spatially within the mitochondria. The dynamin‐related GTPase Optic Atrophy 1 (OPA1) is essential for inner mitochondrial membrane fusion and cristae structure maintenance.
Javaid Jabbar +4 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms.Methods: Large unilamellar vesicles of conventional (LUV VAN),
Andreia Borges Scriboni +8 more
doaj +1 more source
Effect of ultrasound parameters for unilamellar liposome preparation [PDF]
, 2009 Raquel Silva +3 more
openalex +1 more source