Results 221 to 230 of about 151,969 (265)

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

HIV-1 variants in population-based national surveys in sub-Saharan Africa, 2015-2022. [PDF]

AIDS
Ghys PD, Voetsch AC, Justman JE, Patel H, DeVos JR, Brown K, Ussery F, Parekh B, Mahy M, Abimiku A, Aliyu S, Aliyu G, Zuma K, Moyo S, van der Walt C, Kalimashe MN, Ndongmo CB, Kirungi WL, Arimide DA, Hemelaar J, the Study Group to characterize the HIV-1 variant distribution in national surveys in sub-Saharan Africa, 2015–2022 .   +21 more
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Hybrid immunity strategies: heterologous vaccination combined with natural SARS-CoV-2 infection. [PDF]

Front Med (Lausanne)
Huang Y, Zhang X, Miao R, Wang J, Xi X, Pan H, Lu Y, Li D.   +7 more
europepmc   +1 more source

HIV-1 genetic diversity and reverse transcriptase resistance mutations in Benin before dolutegravir era, West Africa. [PDF]

PLoS One
Tchiakpe E, Keke RK, Recordon-Pinson P, Diouara AAM, Andreola ML, Bachabi M, Afangnihoun A, Gbaguidi E, Osawe S, Issiaka Maiga A, Diop-Ndiaye H, Touré-Kane C, Yessoufou A.   +12 more
europepmc   +1 more source

Exploring the repertoire of rhomboid proteases in <i>Cryptosporidium parvum</i> parasite: phylogenesis, structural motifs, and cellular localization in sporozoite cells. [PDF]

Front Cell Infect Microbiol
Vanni I, Pizzi E, Bertuccini L, Ludovisi A, Tosini F.   +4 more
europepmc   +1 more source

Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex. [PDF]

J Biol Chem
Hsu HC, Bonnet I, Bryk R, Li H.
europepmc   +1 more source