Results 231 to 240 of about 294,442 (274)

A missense mutation in the γD crystallin gene (CRYGD) associated with autosomal dominant coral-like cataract linked to chromosome 2q [PDF]

, 2004
Andley, Usha P, Mackay, Donna S, Shiels, Alan   +2 more
core   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Venom Peptides Across Asian and American Tarantulas Utilize Dual Pharmacology to Target Activation and Fast Inactivation of Voltage-Gated Sodium Channels. [PDF]

Toxins (Basel)
Nashikwala AS, Kotapati C, Eagles DA, Lewis RJ, Cardoso FC.   +4 more
europepmc   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Protein Kinase Inhibitors and Oxidative Stress Modulate In Vivo Phosphorylation of <i>Trypanosoma cruzi</i> DNA Polymerase β. [PDF]

Pharmaceutics
Maldonado E, Oyarce M, Canobra P, Rojas E, Urbina F, Tapia JC, Jara L, Miralles VJ, Castillo C, Solari A.   +9 more
europepmc   +1 more source

Caspase-mediated interleukin-18 maturation promotes membrane-associated unconventional secretion and signal transduction in a teleost fish. [PDF]

Mar Life Sci Technol
Yuan L, Xu H, Jiang S.
europepmc   +1 more source

Therapeutic Alternatives to Recombinant Biologics: Mechanistic Framework, Clinical Evidence, and Selection Guidance. [PDF]

Drug Des Devel Ther
Niazi SK.
europepmc   +1 more source

<i>Spodoptera exigua</i> Caspase-4 Enhances the Virulence of Baculovirus by Promoting Host Cell Apoptosis. [PDF]

J Agric Food Chem
Yu Q, Niu Z, Ding X, Li J, Zheng G, Wan F, Li C.   +6 more
europepmc   +1 more source