Results 91 to 100 of about 3,582,598 (362)
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2017 Dependence on a parameter $\lambda$ are established for existence, nonexistence and multiplicity results for nontrivial solutions to a nonlinear Atıcı–Eloe fractional difference equation $$\Delta^{\nu}y(t-2)-\beta \Delta^{\nu-2}y(t-1) = \lambda f(t+\nu ...
Aijun Yang, Johnny Henderson, Helin Wang
doaj +1 more source
Deviance or uniqueness, harmony or conformity? A cultural analysis.
, 1999 Uniqueness has positive connotations of freedom and independence in American culture, whereas conformity has positive connotations of connectedness and harmony in East Asian culture.
Heejung S. Kim, H. Markus
semanticscholar +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
A Lipschitz condition along a transversal foliation implies local uniqueness for ODEs
Electronic Journal of Qualitative Theory of Differential Equations, 2018 We prove the following result: if a continuous vector field $F$ is Lipschitz when restricted to the hypersurfaces determined by a suitable foliation and a transversal condition is satisfied at the initial condition, then $F$ determines a locally unique ...
José Ángel Cid, F. Adrián Tojo
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Singular boundary-value problems with variable coefficients on the positive half-line
Electronic Journal of Differential Equations, 2013 This work concerns the existence and the multiplicity of solutions for singular boundary-value problems with a variable coefficient, posed on the positive half-line.
Smail Djebali, Ouiza Saifi, Samira Zahar
doaj
On the uniqueness of limit cycle for certain Liénard systems without symmetry
Electronic Journal of Qualitative Theory of Differential Equations, 2018 The problem of the uniqueness of limit cycles for Liénard systems is investigated in connection with the properties of the function $F(x)$.
Makoto Hayashi +2 more
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source