Results 141 to 150 of about 3,582,598 (362)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Svalbard in International Politics 1871-1925: The Solution of a Unique International Problem [PDF]
, 1955 Oscar J. Falnes, Trygve Mathisen
openalex +1 more source
Theoretical Computer Science, 2006 AbstractA uniqueness type system is used to distinguish values which are referenced at most once from values which may be referenced an arbitrary number of times in a program. Uniqueness type systems are used in the Clean and Mercury programming languages to provide efficiently updatable data-structures and I/O without compromising referential ...
openaire +2 more sources
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
On the Uniqueness of Solutions of a System of Ordinary Differential Equations [PDF]
, 1950 Tarô Yoshizawa, Kyûzô Hayashi
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Complex Ginzburg-Landau equations with a delayed nonlocal perturbation
Electronic Journal of Differential Equations, 2020 We consider an initial boundary value problem of the complex Ginzburg-Landau equation with some delayed feedback terms proposed for the control of chemical turbulence in reaction diffusion systems. We consider the equation in a bounded domain $\Omega\
Jesus Ildefonso Diaz +3 more
doaj
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
A Unique Case of Auto-immune Erythrocyte Sensitization [PDF]
, 1958 J. Darnborough
openalex +1 more source