Results 81 to 90 of about 11,432,263 (339)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
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Treatment of International Human Rights Violations in the United States [PDF]
, 2014 In our day and age, the violation of human rights has become a matter of international concern. This article is focused on the sharing of those concerns by the United States, in particular as manifested by the treatment of human rights violations in ...
Van Der Vyver, Johan D.
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Foreign service dispatches: Mozambique. LourencoMarques_1969-12-18-A131 [PDF]
, 1969 Subject: Current Economic Development in ...
United States. Department of State.
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The Asian-American Labor Force in the Recovery [PDF]
, 2011 [Excerpt] Asian-Americans and Hawaiians and Pacific Islanders are a growing share of the United States labor market. They are also a diverse population who identify their ethnicity as Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese and ...
United States Department of Labor
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Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
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ZOROTYPUS HUBBARDI, A NEW SPECIES OF THE ORDER ZORAPTERA FROM THE UNITED STATES [PDF]
, 1918 Andrew N. Caudell
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