Introduction Vaccination is the most effective method to control the prevalence of seasonal influenza and the most widely used influenza vaccine is the inactivated influenza vaccine (IIV).
Hua Shi, Ted M. Ross
doaj +1 more source
TIV vaccination modulates host responses to influenza virus infection that correlate with protection against bacterial superinfection [PDF]
Background: Influenza virus infection predisposes to secondary bacterial pneumonia. Currently licensed influenza vaccines aim at the induction of neutralizing antibodies and are less effective if the induction of neutralizing antibodies is low and/or the
Choi, Angela +4 more
core +2 more sources
Whispers of Pathogens; Social Contagion in Infectious Disease Dynamics: A Review
ABSTRACT Background and Aims Infectious disease dynamics are deeply intertwined with social structures, behaviors, and information systems. This narrative review examines how social factors conceptualized through the integrated lens of “social contagion” within a syndemic framework shape infectious disease patterns from January 2000 to January 2024 ...
Sayed Mortaza Fayez
wiley +1 more source
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
Abstract Introduction Although state, federal, and professional guidelines stipulate the need for informed consent for toxicology testing during pregnancy, consent is often inadequately obtained. The objective of this study was to explore birthing person and obstetric clinician experiences with consent for toxicology testing during pregnancy.
Leah N. Schwartz +7 more
wiley +1 more source
SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer +2 more
wiley +1 more source
Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery
This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk +9 more
wiley +1 more source
Identification and In Silico Characterization of a Conserved Peptide on Influenza Hemagglutinin Protein: A New Potential Antigen for Universal Influenza Vaccine Development. [PDF]
Khalaj-Hedayati A +6 more
europepmc +1 more source
Pandemic Flu Preparedness: Lessons From the Frontlines [PDF]
Outlines early lessons from the 2009 H1N1 influenza outbreak and recommendations for strengthening the U.S. core public health capacity, including vaccine stockpile and development, planning and coordination, infrastructure, and surge capacity and ...
core

