Results 1 to 10 of about 167,128 (158)

Development of a Multi-Epitope Universal mRNA Vaccine Candidate for Monkeypox, Smallpox, and Vaccinia Viruses: Design and In Silico Analyses

Viruses, 2023
Notwithstanding the presence of a smallpox vaccine that is effective against monkeypox (mpox), developing a universal vaccine candidate against monkeypox virus (MPXV) is highly required as the mpox multi-country outbreak has increased global concern ...
Nino Rcheulishvili, Jiawei Mao, Dimitri Papukashvili, Shunping Feng, Cong Liu, Xidan Yang, Jihui Lin, Yunjiao He, Peng George Wang   +8 more
doaj   +3 more sources

Options and Obstacles for Designing a Universal Influenza Vaccine

Viruses, 2014
Since the discovery of antibodies specific to a highly conserved stalk region of the influenza virus hemagglutinin (HA), eliciting such antibodies has been considered the key to developing a universal influenza vaccine that confers broad-spectrum ...
Yo Han Jang, Baik Lin Seong
doaj   +3 more sources

Progress towards the Development of a Universal Influenza Vaccine

Viruses, 2022
Influenza viruses are responsible for millions of cases globally and significantly threaten public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 years and some of the viruses have resulted in high mortality in humans ...
Wen-Chien Wang, Ekramy E. Sayedahmed, Suryaprakash Sambhara, Suresh K. Mittal   +3 more
doaj   +3 more sources

Designing a multi-epitope universal vaccine for concurrent infections of SARS-CoV-2 and influenza viruses using an immunoinformatics approach [PDF]

BMC Infectious Diseases
Background Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and influenza viruses share several conserved epitopes that can be utilized for the development of universal vaccines.
Shirin Mohammadipour, Hadi Tavakkoli, Seyedeh Narges Fatemi, Aram Sharifi, Peyman Mahmoudi   +4 more
doaj   +2 more sources

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]

, 2013
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
A Endo, A Portela, AJ McMichael, Alexandria David, Andrew Pekosz, AS McKee, AT Heiny, B Zhou, CJ Wei, CS Ambrose, D Corti, D Grimm, D Zehn, DM Carragher, DT O’Hagan, E de Wit, F Crawford, F Rahman, GA Poland, GE Price, GT Belz, H Hikono, H Hohn, JB Ulmer, JE McElhaney, Jieru Wang, John W. Kappler, JP Christensen, JW Yewdell, K Thueng-in, L Guo, Laura Noges, LE Brown, LL Shu, M Schotsaert, M Wang, Megan K. L. MacLeod, MK MacLeod, MM Cox, MW LaMere, MW Lamere, N Garcon, Niyun Jin, P Marrack, Philippa Marrack, R Sebastian, RA Medina, SL Giannini, T Lambe, TM Wilkinson, U Kees, Y Furuya   +51 more
core   +10 more sources

Development of a Universal Epitope-Based Influenza Vaccine and Evaluation of Its Effectiveness in Mice

Vaccines, 2022
Vaccination is an effective and economically viable means of protection against the influenza virus, but due to rapid viral evolution, modern seasonal vaccines are not effective enough.
Ramil R. Mintaev, Dina V. Glazkova, Olga V. Orlova, Elena V. Bogoslovskaya, German A. Shipulin   +4 more
doaj   +1 more source

Salmonella enterica serovar Choleraesuis vector delivering a dual-antigen expression cassette provides mouse cross-protection against Streptococcus suis serotypes 2, 7, 9, and 1/2

Veterinary Research, 2022
A universal vaccine protecting against multiple serotypes of Streptococcus suis is urgently needed to improve animal welfare and reduce the consumption of antibiotics.
Yu-an Li, Yanni Sun, Yang Fu, Yuqin Zhang, Quan Li, Shifeng Wang, Huoying Shi   +6 more
doaj   +1 more source

M2e-Based Influenza Vaccines with Nucleoprotein: A Review

Vaccines, 2021
Discovery of conserved antigens for universal influenza vaccines warrants solutions to a number of concerns pertinent to the currently licensed influenza vaccines, such as annual reformulation and mismatching with the circulating subtypes.
Mei Peng Tan, Wen Siang Tan, Noorjahan Banu Mohamed Alitheen, Wei Boon Yap   +3 more
doaj   +1 more source

Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches

Viruses, 2020
Influenza is one of the top threats to public health. The best strategy to prevent influenza is vaccination. Because of the antigenic changes in the major surface antigens of influenza viruses, current seasonal influenza vaccines need to be updated every
Sijia Tang, Wandi Zhu, Bao-Zhong Wang
doaj   +1 more source

Targeting Antigens for Universal Influenza Vaccine Development

Viruses, 2021
Traditional influenza vaccines generate strain-specific antibodies which cannot provide protection against divergent influenza virus strains. Further, due to frequent antigenic shifts and drift of influenza viruses, annual reformulation and revaccination
Quyen-Thi Nguyen, Young-Ki Choi
doaj   +1 more source