Results 121 to 130 of about 1,366,602 (255)

Antigenic variability and conserved epitopes in influenza: Challenges and opportunities for universal vaccine design

Duazary
Influenza is a highly transmissible viral infection characterized by significant antigenic variability, leading to seasonal epidemics and occasional pandemics.
Ricardo Enrique Mejía-Melgarejo, Juan Carlos Dib-Diazgranados, Xilene Mendoza-Sánchez, Alexander Rodríguez-Sanjuán, Yoleydis Elena Collazos-Lara, Homero Gabriel San Juan-Vergara, Walter Ángel Martínez-De La Rosa   +6 more
doaj   +1 more source

Design and Assessment of a Novel In Silico Approach for Developing a Next-Generation Multi-Epitope Universal Vaccine Targeting Coronaviruses. [PDF]

Microorganisms, 2023
Rasheed MA, Raza S, Alonazi WB, Ashraf MA, Navid MT, Aslam I, Iqbal MN, Rahman SU, Riaz MI.   +8 more
europepmc   +1 more source

Updated recommendations of the International dengue Initiative expert group for CYD-TDV vaccine implementation in Latin America

, 2019
Dengue disease represents a large and growing global threat to public health, causing a significant burden to health systems of endemic countries. For countries considering vaccination as part of their Integrated Management Strategy for Prevention and ...
Giambernardino, H. I.G., Castellanos-Martinez, J. M., Delrieu, Isabelle, Avila-Aguero, Maria L., Torres, Jaime, Torres, C. N, Falleiros-Arlant, Luiza Helena, Brea, J., Gessner, Bradford D., Mascareñas, Abiel   +9 more
core   +1 more source

Digital Transformation of Medicines Regulation in Africa—Perspectives from a Stakeholder Convening

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory authorities worldwide are developing strategies to integrate artificial intelligence (AI) into the lifecycle of health products, technologies, and medicines. While regulators share goals of improving efficiency, strengthening decision‐making, and protecting public health, their approaches differ according to institutional structures ...
Christelna Reyneke, Boitumelo Semete‐Makokotlela, Varnika Singh, Khanyisile Nkuku, Madelein Terblanche, Ezekiel T Mukanga, Nancy Ngum, Kudakwashe Dandajena, McNeil Chimus Mhango, Paulyne Wairimu, John Mwangi, Dominique Lagrave, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

A bivalent inactivated influenza vaccine incorporating epitope-optimized surface proteins confers cross-protective immunity against H9N2 influenza virus

Emerging Microbes and Infections
The H9N2 avian influenza virus (AIV) has caused substantial economic losses to the global poultry industry and poses a zoonotic threat to humans. Vaccination constitutes a pivotal strategy for the prevention and control of H9N2 AIVs. However, the ongoing
Mengchan Hao, Yiwei Guan, Meng Xu, Wenxue Yang, Yanhai Wang, Yuan Zhang, Jianjun Chen   +6 more
doaj   +1 more source

Challenges and developments in universal vaccine design against SARS-CoV-2 variants. [PDF]

NPJ Vaccines, 2022
Zhao F, Zai X, Zhang Z, Xu J, Chen W.
europepmc   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Sights set on universal vaccine. [PDF]

New Sci, 2021
Lawton G.
europepmc   +1 more source

Concomitant administration of live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) and measles, mumps, rubella (MMR) vaccine: Randomized study in toddlers in Taiwan

, 2017
Background: Japanese encephalitis (JE) is the most important cause of viral encephalitis in Asia. ;Methods: In this randomized, open-label, multicenter trial in 550 children aged 12 to 18 months in Taiwan, children received one dose of JE-CV and one dose
Huang, Li-Min;Lin, Tzou-Yien;Chiu, Cheng-Hsun;Chiu, Nan-Chang;Chen, Po-Yen;Yeh, Shu-Jen;Boaz, Mark;Hutagalung, Yanee;Bouckenooghe, Alain;Feroldi, Emmanuel, 黃立民   +1 more
core   +1 more source

The Influence of Ethical Ideologies on Corporate Social Performance in Small and Medium‐Sized Enterprises in the United Kingdom

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Research addressing the microfoundations of corporate social performance (CSP) in small and medium‐sized enterprises (SMEs) remains sparse. This paper aims to investigate how SME managers' ethical ideology affects CSP and examines the mediating role of their CSR orientation (CSRO): economic, legal, ethical, and philanthropic.
Sarah Mohammad Suleiman Alsyoof, Vasa László, Tamás Sneider   +2 more
wiley   +1 more source