Viruses, 2023 Notwithstanding the presence of a smallpox vaccine that is effective against monkeypox (mpox), developing a universal vaccine candidate against monkeypox virus (MPXV) is highly required as the mpox multi-country outbreak has increased global concern ...
Nino Rcheulishvili +8 more
doaj +2 more sources
Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine. [PDF]
Vaccines (Basel), 2020 Influenza virus infections represent a serious public health threat and account for significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics.
Lopez CE, Legge KL.
europepmc +2 more sources
Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations for Universal Vaccine Development. [PDF]
ImmunohorizonsDespite the success of global vaccination programs in slowing the spread of COVID-19, these efforts have been hindered by the emergence of new SARS-CoV-2 strains capable of evading prior immunity.
Magazine N +6 more
europepmc +2 more sources
Genomic Diversity and Hotspot Mutations in 30,983 SARS-CoV-2 Genomes: Moving Toward a Universal Vaccine for the "Confined Virus"? [PDF]
Pathogens, 2020 The COVID-19 pandemic has been ongoing since its onset in late November 2019 in Wuhan, China. Understanding and monitoring the genetic evolution of the virus, its geographical characteristics, and its stability are particularly important for controlling ...
Alouane T +23 more
europepmc +2 more sources
A universal coronavirus vaccine [PDF]
Science, 2021 COVID-19 has already produced catastrophic social, economic, and public health consequences, with more than 107 million documented cases and 2.3 million deaths.
W. Koff, S. Berkley
semanticscholar +3 more sources
Prepare for the Future: Dissecting the Spike to Seek Broadly Neutralizing Antibodies and Universal Vaccine for Pandemic Coronaviruses. [PDF]
Front Mol Biosci, 2020 Learning from the lengthy fight against HIV-1, influenza, and Ebola virus infection, broadly neutralizing antibodies (bnAbs), directed at conserved regions of surface proteins crucial to virus entry (Env, hemagglutinin, and GP, respectively), are an ...
Vangelista L, Secchi M.
europepmc +2 more sources
Design and Assessment of a Novel In Silico Approach for Developing a Next-Generation Multi-Epitope Universal Vaccine Targeting Coronaviruses [PDF]
Microorganisms, 2023 In the past two decades, there have been three coronavirus outbreaks that have caused significant economic and health crises. Biologists predict that more coronaviruses may emerge in the near future.
Muhammad Asif Rasheed +8 more
doaj +2 more sources
Development of Influenza B Universal Vaccine Candidates Using the "Mosaic" Hemagglutinin Approach. [PDF]
J Virol, 2019 This work reports a universal influenza B virus vaccination strategy based on focusing antibody responses to conserved head and stalk epitopes of the hemagglutinin.
Sun W +6 more
europepmc +2 more sources
Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens. [PDF]
J Infect Dis, 2019 Influenza viruses routinely acquire mutations in their hemagglutinin (HA) and neuraminidase (NA) glycoproteins that abrogate binding of pre-existing antibodies in a process known as antigenic drift.
Zost SJ, Wu NC, Hensley SE, Wilson IA.
europepmc +2 more sources
Progress towards the Development of a Universal Influenza Vaccine
Viruses, 2022 Influenza viruses are responsible for millions of cases globally and significantly threaten public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 years and some of the viruses have resulted in high mortality in humans ...
Wen-Chien Wang +3 more
doaj +2 more sources