A Universal Vaccine against Leptospirosis: Are We Going in the Right Direction? [PDF]
Front Immunol, 2017 Leptospirosis is the most widespread zoonosis in the world and a neglected tropical disease estimated to cause severe infection in more than one million people worldwide every year that can be combated by effective immunization.
Grassmann AA +3 more
europepmc +2 more sources
Targeting Antigens for Universal Influenza Vaccine Development
Viruses, 2021 Traditional influenza vaccines generate strain-specific antibodies which cannot provide protection against divergent influenza virus strains. Further, due to frequent antigenic shifts and drift of influenza viruses, annual reformulation and revaccination
Quyen-Thi Nguyen, Young-Ki Choi
doaj +2 more sources
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine [PDF]
npj Vaccines, 2022 We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the drawbacks of low efficacy by monomeric domain-based ...
Subbiah Jeeva +8 more
openalex +2 more sources
Universal vaccine against respiratory syncytial virus A and B subtypes. [PDF]
PLoS One, 2017 Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in infants, young children, and the elderly. Two subtypes of RSV, A and B, circulate alternately at 1-2-year intervals during epidemics.
Lee JY, Chang J.
europepmc +2 more sources
M2e-based universal influenza A vaccine [PDF]
Vaccines, 2009 The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these ...
Walter Fiers +7 more
openalex +5 more sources
Strategies targeting hemagglutinin cocktail as a potential universal influenza vaccine
Frontiers in Microbiology, 2022 Vaccination is the most effective means of protecting people from influenza virus infection. The effectiveness of existing vaccines is very limited due to antigenic drift of the influenza virus.
Xuejie Liu +6 more
doaj +2 more sources
Safety and Immunogenicity of OVX836, a Nucleoprotein-Based Universal Influenza Vaccine, Co-Administered with Fluarix® Tetra, a Seasonal Hemagglutinin-Based Vaccine [PDF]
VaccinesBackground/Objectives: The combination of a hemagglutinin antigen (HA)-based inactivated influenza vaccine (IIV; Fluarix® Tetra; GlaxoSmithKline) with a nucleoprotein (NP)-based vaccine, such as OVX836, should increase the efficacy of influenza vaccines ...
Nicola Groth +6 more
doaj +2 more sources
Integrated organ immunity: a path to a universal vaccine. [PDF]
Nat Rev ImmunolPulendran B.
europepmc +2 more sources
HPV vaccine: positive insights from universal adolescent HepB vaccination [PDF]
Journal of Epidemiology and Community Health, 2007 The introduction of universal adolescent HPV vaccination in schools has a positive outlook Preventing cervical cancer by vaccination has become a reality, complementing highly successful screening programmes. One vaccine against human papillomavirus (HPV) is already licensed (Gardasil®, Sanofi Pasteur), and approval for a second (Cervarix®, GSK) is ...
J. Claire Cameron +5 more
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Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]
, 2013 Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
A Endo +51 more
core +6 more sources