Results 61 to 70 of about 1,612,376 (366)

A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering

bioRxiv, 2021
A “universal” vaccine design platform that can rapidly generate multiplex vaccine candidates is critically needed to control future pandemics. Here, using SARS-CoV-2 pandemic virus as a model, we have developed such a platform by CRISPR engineering of ...
Jingen Zhu, N. Ananthaswamy, Swati Jain, Himanshu Batra, Wei-Chun Tang, Douglass A. Lewry, Michael L. Richards, S. David, Paul B. Kilgore, J. Sha, A. Drelich, C. Tseng, A. Chopra, V. Rao   +13 more
semanticscholar   +1 more source

The effect of respiratory viruses on immunogenicity and protection induced by a candidate universal influenza vaccine in mice.

PLoS ONE, 2019
Current approaches to influenza control rely on vaccines matched to viruses in circulation. Universal influenza vaccines would offer the advantage of providing broad protection against diverse strains of influenza virus.
Janelle Rowell, Chia-Yun Lo, Graeme E Price, Julia A Misplon, Roberta L Crim, Priyanka Jayanti, Judy Beeler, Suzanne L Epstein   +7 more
doaj   +1 more source

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

Vaccines, 2018
The antigenically conserved hemagglutinin stalk region is a target for universal influenza virus vaccines since antibodies against it can provide broad protection against influenza viruses of different subtypes.
Sun-Young Sunwoo, Michael Schotsaert, Igor Morozov, Anne Sally Davis, Yuhao Li, Jinhwa Lee, Chester McDowell, Philip Meade, Raffael Nachbagauer, Adolfo García-Sastre, Wenjun Ma, Florian Krammer, Juergen A. Richt   +12 more
doaj   +1 more source

Immune Responses Elicited by Live Attenuated Influenza Vaccines as Correlates of Universal Protection against Influenza Viruses

Vaccines, 2021
Influenza virus infection remains a major public health challenge, causing significant morbidity and mortality by annual epidemics and intermittent pandemics. Although current seasonal influenza vaccines provide efficient protection, antigenic changes of
Yo Han Jang, Baik L. Seong
doaj   +1 more source

Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine

Vaccines, 2021
Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza ...
Brianna L. Bullard, E. Weaver
semanticscholar   +1 more source

University vaccine campaign increases meningococcal ACWY vaccine coverage [PDF]

Public Health, 2017
The file associated with this record is embargoed until 12 months after the date of publication. The final published version may be available through the links above. Following the embargo period the above license applies. ; In this study, we report MenACWY vaccine coverage in first year students arriving at the University of Nottingham (UoN) in ...
D.P.J. Turner, N.J. Oldfield, C.D. Bayliss   +2 more
openaire   +4 more sources

Strengthening Vaccine Safety Systems, Research, and Regional Collaboration in Africa: A Call to Action

Vaccines
The 8th meeting of the African Advisory Committee on Vaccine Safety (AACVS), constituted in 2021, convened by the Vaccine Research and Innovation Unit within the Vaccine Preventable Diseases Program, WHO Regional Office for Africa, was held virtually ...
Beckie N. Tagbo, Chioma S. Ejekam, Winfred Oppong-Amoako, Tene Marceline Yameogo, Afework Mitiku, Dorothy O. Esangbedo, Nelisiwe Khuzwayo, Gugu Mahlangu, Samia M. Badar, Edinam A. Agbenu, Rhanda M. Adechina, Kwasi A. Nyarko   +11 more
doaj   +1 more source

Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head

Vaccines, 2015
Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes.
Lidewij C. M. Wiersma, Guus F. Rimmelzwaan, Rory D. de Vries   +2 more
doaj   +1 more source

Universal Influenza Virus Neuraminidase Vaccine Elicits Protective Immune Responses against Human Seasonal and Pre-pandemic Strains

Journal of Virology, 2021
The development and distribution of a universal influenza vaccine would alleviate global economic and public health stress from annual influenza virus outbreaks.
A. L. Skarlupka, Anne-Gaelle Bebin-Blackwell, Spencer F. Sumner, T. Ross   +3 more
semanticscholar   +1 more source

Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. [PDF]

, 2019
Background: The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice.
Abraham, Tara S., Baybutt, Trevor R., Flickinger, John C., Hyslop, Terry, Kraft, Walter K., Sato, Takami, Snook, Adam E., Waldman, Scott A., Xiang, Bo, Zhan, Tingting   +9 more
core   +3 more sources