Results 61 to 70 of about 2,696 (268)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A comparative syntax of internally-headed relative clauses in Gur
Glossa, 2017 Gur (or Mabia) languages which are spoken in West Africa have so-called internally-headed relative clauses (IHRCs), but they have not received serious attention in syntactic and typological research on IHRCs.
Adams Bodomo +5 more
doaj +2 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Making Universal Policies Universal
International Joint Conference on Autonomous Agents and Multiagent SystemsThe development of a generalist agent capable of solving a wide range of sequential decision-making tasks remains a significant challenge. We address this problem in a cross-agent setup where agents share the same observation space but differ in their action spaces.
Hoepner, Niklas +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Does Ockham’s razor matter to the problem of universals?
GriotThis paper investigates how Ockham’s Razor can be applied to compare and evaluate solutions to the Problem of Universals. Initially, I discuss three formulations of this principle.
Valdetonio Pereira de Alencar
doaj +1 more source
What in the World is Universe? : A Prime Example [PDF]
Философия и космология, 2016 This writing attempts to capture mind and matter to rational description by focusing on disparity between scientific method as it extracts concepts and discards particulars and ordinary cognitive functioning that extends from proximal experience ...
Marvin E. Kirsh
doaj
Tapuya, 2019 Decades after a violent war that re-established British control over the Falkland Islands (Malvinas in Spanish), commercial fishing regimes and offshore oil discoveries have led Argentina and the United Kingdom to reassert their respective sovereignty ...
James J. A. Blair
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source