Results 81 to 90 of about 16,264 (308)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Language universals and typology in the UNITYP framework [PDF]
, 1990 Why should we engage in language universals research and language typology? What do we want to explain? It is a fact that, although languages differ significantly and considerably.
Seiler, Hansjakob
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Does Ockham’s razor matter to the problem of universals?
GriotThis paper investigates how Ockham’s Razor can be applied to compare and evaluate solutions to the Problem of Universals. Initially, I discuss three formulations of this principle.
Valdetonio Pereira de Alencar
doaj +1 more source
What in the World is Universe? : A Prime Example [PDF]
Философия и космология, 2016 This writing attempts to capture mind and matter to rational description by focusing on disparity between scientific method as it extracts concepts and discards particulars and ordinary cognitive functioning that extends from proximal experience ...
Marvin E. Kirsh
doaj
Tapuya, 2019 Decades after a violent war that re-established British control over the Falkland Islands (Malvinas in Spanish), commercial fishing regimes and offshore oil discoveries have led Argentina and the United Kingdom to reassert their respective sovereignty ...
James J. A. Blair
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Language form compression in modern Russian speech
Russian Language StudiesCompressive word formation results from the active tendency to save speech effort and, accordingly, to save linguistic means, which makes its research relevant.
Elena M. Markova
doaj +1 more source
Some Introductory Words For Two Little Earth Cousins
Journal of Applied Hermeneutics, 2014 This article is an introduction to the subsequent one by Jodi Latremouille's "My Treasured Relation." It demonstrates that hermeneutic work is always about the application of particular cases to universals, demanding of universals to listen to the ...
David W Jardine
doaj +1 more source