Results 41 to 50 of about 1,177,514 (265)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Die Medizinische Bibliothek der RWTH Aachen / The Medical Library of the RWTH Aachen University
GMS Medizin – Bibliothek – Information, 2009 The paper introduces the medical library of the RWTH Aachen University. It starts with a short historical review and describes the status of the medical library inside the library system of the university.
Reimann, Iris
doaj
Bilkent Üniversitesi Kütüphanesi : Müzik Odası ve Görsel İşitsel Koleksiyon / Bilkent University Library : Music Room and Audio-Visual Collection [PDF]
Bilgi Dünyası, 2004 This paper describes the development of the Music Room and Audio- Visual Collection of Bilkent University Library together with the aim, missions and future plans of the mentioned service.
Özden Demircioğlu, Muharrem Yılmaz
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
FEATURES OF THE EDUCATIONAL PROCESS IN THE INFORMATION AND TELECOMMUNICATIONS SOCIETY
University Library at a New Stage of Social Communications Development, 2020 Objective. The purpose of this paper is to analyze the impact of the development of information and communication technologies in society on the state of the educational process.
Olha V. TURMYS
doaj +1 more source
Libraries in Major Universities in Lebanon [PDF]
Libri, 2001 This paper puts the contemporary situation of some Lebanese university libraries in a broader context. It introduces the country, and outlines its higher education system, library science education, professional association, and publishing activity. It reviews the varying situations in the libraries of 3 selected Universities - the American University ...
Al Khatib, Sahar, Johnson, Ian M.
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
College Students’ Preferences for Reading Desk Partition Designs in University Libraries
Tūzī yǔ dàng’àn xuékān, 2015 This study intends to find out college students' preferences for library reading desk partition designs and their habits of using reading desks in relation to the designs. The research data are 4,725 questionnaires replied by college students. This study
Koli Chen
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source