Results 51 to 60 of about 94,207,166 (295)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Die Medizinische Bibliothek der RWTH Aachen / The Medical Library of the RWTH Aachen University
GMS Medizin – Bibliothek – Information, 2009 The paper introduces the medical library of the RWTH Aachen University. It starts with a short historical review and describes the status of the medical library inside the library system of the university.
Reimann, Iris
doaj
Bilkent Üniversitesi Kütüphanesi : Müzik Odası ve Görsel İşitsel Koleksiyon / Bilkent University Library : Music Room and Audio-Visual Collection [PDF]
Bilgi Dünyası, 2004 This paper describes the development of the Music Room and Audio- Visual Collection of Bilkent University Library together with the aim, missions and future plans of the mentioned service.
Özden Demircioğlu, Muharrem Yılmaz
doaj
University Library at a New Stage of Social Communications Development, 2020 Objective. This study aims 1) to acquire new information on alternative conference formats, including in the field of Library and Information Science (LIS), which have arisen as a result of the COVID-19 pandemic and restrictions on physical communication;
Tetiana O. KOLESNYKOVA
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
College Students’ Preferences for Reading Desk Partition Designs in University Libraries
Tūzī yǔ dàng’àn xuékān, 2015 This study intends to find out college students' preferences for library reading desk partition designs and their habits of using reading desks in relation to the designs. The research data are 4,725 questionnaires replied by college students. This study
Koli Chen
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source