Results 121 to 130 of about 332,918 (306)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Top ranking economics journals impact variability and a ranking update to the year 2002 [PDF]

In this paper I address four questions concerning the quality of scientific economic papers. First, I validate the ex-ante procedure of computing the average impact of economic papers by comparing its results with the expost values.
Pedro C. Vieira
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ranking Web of Universities: Is Webometrics a Reliable Academic Ranking?

, 2021
Global university rankings continue to gain growing interest and have high visibility from all stakeholders. Of these, Webometrics Ranking (WR) faces many criticisms about its function.
Ibrahim Shehatta; Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Khalid Mahmood; University of the Punjab, Lahore, Pakistan, Abdullah M. Al-Rubaish; Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia   +2 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Eğitim Bilimleri Odağında Türkiye’deki Üniversitelerin Değerlendirilmesi: İkincil Veri Analizi

Üniversite Araştırmaları Dergisi
Bu çalışmada, 93 ülkede 2500 üniversiteden elde edilen verileri birçok kritere göre sıralayan Times Higher Education World University Rankings (THE) tarafından yapılan değerlendirme sonuçlarının Türkiye’de faaliyet gösteren üniversiteler odağında analiz ...
Murat Korucuk
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Telling experts from spammers: expertise ranking in folksonomies

, 2009
With a suitable algorithm for ranking the expertise of a user in a collaborative tagging system, we will be able to identify experts and discover useful and relevant resources through them. We propose that the level of expertise of a user with respect to
Noll, Michael, Ching-man Au Yeung, Meinel, Christoph, Gibbins, Nicholas, Michael G. Noll, Nigel Shadbolt, Nicholas Gibbins, Au Yeung, Ching Man, Christoph Meinel, Shadbolt, Nigel   +9 more
core   +1 more source

Webometric Ranking of European Universities

Procedia - Social and Behavioral Sciences, 2012
In year 2004 Aguillo and colleagues launched the Webometrics Ranking of World's Universities (www.webometrics.info), the ranking of universities by their presence on the Internet with the aim of promoting and enriching the content of university web pages.
openaire   +2 more sources