Results 31 to 40 of about 3,827,148 (296)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Transformations in academic work and faculty perceptions of artificial intelligence in higher education

open access: yesFrontiers in Education
Technologies based on artificial intelligence are transforming teaching practices in higher education. However, many university faculty members still face difficulties in incorporating these tools in a critical, ethical, and pedagogically meaningful way.
Jorge Buele, Leonel Llerena-Aguirre
doaj   +1 more source

Teaching at university

open access: yesEducation Economics, 2022
Using the rights contained in the Freedom of Information Act, we collected data on the teaching undertaken by staff at 52 UK universities. In contrast to workload modelling, our data reveals the extent of the variation in contact hours by institution, subject, and seniority.
Ambler, Rachel   +2 more
openaire   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Effets perçus de l’engagement en formation à distance sur les pratiques et les compétences des enseignants du supérieur

open access: yesDistances et Médiations des Savoirs, 2017
This case study focuses on the perception of higher education teachers about the evolution of their practice and their skills, linked to the use of technology and distance education.
Georges Ferone
doaj   +1 more source

Faculty Excellence [PDF]

open access: yes, 2000
Each year, the University of New Hampshire selects a small number of its outstanding faculty for special recognition of their achievements in teaching, scholarship and service.
University of New Hampshire
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Overview of Didactic Methodical Organization of University Teaching by Bologna Concept of Higher Education [PDF]

open access: yesInterdisciplinary Description of Complex Systems, 2016
Reassessment of the existing didactic-methodological organization within the University lectures as well as the role of students and University lecturers is a result of the current process of higher education reforms.
Nedim Čirić
doaj   +1 more source

Faculty Excellence [PDF]

open access: yes, 1997
Each year, the University of New Hampshire selects a small number of its outstanding faculty for special recognition of their achievements in teaching, scholarship and service.
University of New Hampshire
core   +1 more source

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