Results 261 to 270 of about 1,161,651 (341)

Unnatural amino acid mutagenesis-based enzyme engineering

Trends in Biotechnology, 2015
Traditional enzyme engineering relies on substituting one amino acid by one of the other 19 natural amino acids to change the functional properties of an enzyme. However, incorporation of unnatural amino acids (UAAs) has been harnessed to engineer efficient enzymes for biocatalysis.
Yuvaraj, Ravikumar, Saravanan Prabhu, Nadarajan, Tae Hyeon, Yoo, Chong-soon, Lee, Hyungdon, Yun   +4 more
openaire   +3 more sources

Controlled Genetic Encoding of Unnatural Amino Acid in Protein Nanopore.

Angewandte Chemie, 2023
Conventional protein engineering methods for modifying protein nanopore are typically limited to 20 natural amino acids, which restricts the diversity of nanopore in structure and function.
Xue-yuan Wu, Meng-Yin Li, Shaojun Yang, Jie Jiang, Yilun Ying, Peng R. Chen, Yitao Long   +6 more
semanticscholar   +1 more source

A general supramolecular approach to regulate protein functions by cucurbit[7]uril and unnatural amino acid recognition.

Angewandte Chemie, 2021
Regulation of specific protein function is of great importance for both research and therapeutic development. Many small or large molecules have been developed to control specific protein function, but there is a lack of a universal approach to regulate ...
Wenbing Cao, Xuewen Qin, Yong Wang, Zhen Dai, X. Dai, Haoyu Wang, Weimin Xuan, Yingming Zhang, Yu Liu, Tao Liu   +9 more
semanticscholar   +1 more source

Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)-H Bonds.

Organic Letters, 2022
The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation-radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp3)-H bonds has not been fully explored.
Florence Babawale, K. Murugesan, Rok Narobe, B. König   +3 more
semanticscholar   +1 more source

Highly Enantioselective Synthesis of N-Unprotected Unnatural α-Amino Acid Derivatives by Ruthenium-Catalyzed Direct Asymmetric Reductive Amination.

Angewandte Chemie, 2022
A highly enantioselective Ru-catalyzed direct asymmetric reductive amination of α-keto amides with ammonium salts has been disclosed, efficiently offering valuable enantioenriched N -unprotected unnatural α-amino acid derivatives bearing a broad range of
Le’an Hu, Yuanhua Wang, Lei Xu, Qin Yin, Xumu Zhang   +4 more
semanticscholar   +1 more source

Unnatural Amino‐Acid‐Based Star‐Shaped Poly(l‐Ornithine)s as Emerging Long‐Term and Biofilm‐Disrupting Antimicrobial Peptides to Treat Pseudomonas aeruginosa‐Infected Burn Wounds

Advanced Healthcare Materials, 2020
Peptide‐based antimicrobial materials are recognized as promising alternatives to antibiotics to circumvent the emergence of antibiotic‐resistant bacteria or to combat multiple resistant bacteria by targeting the bacterial cell membrane.
M. Pan, Chao Lu, Maochao Zheng, Wen Zhou, Fuling Song, Weidong Chen, Fen Yao, Daojun Liu, Jianfeng Cai   +8 more
semanticscholar   +1 more source

Antibody Conjugates with Unnatural Amino Acids

Molecular Pharmaceutics, 2015
Antibody conjugates are important in many areas of medicine and biological research, and antibody-drug conjugates (ADCs) are becoming an important next generation class of therapeutics for cancer treatment. Early conjugation technologies relied upon random conjugation to multiple amino acid side chains, resulting in heterogeneous mixtures of labeled ...
Trevor J, Hallam, Erik, Wold, Alan, Wahl, Vaughn V, Smider   +3 more
openaire   +2 more sources

Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural α-Amino Acid Synthesis.

Journal of the American Chemical Society, 2020
Unnatural α-amino acids are invaluable building blocks in synthetic organic chemistry and could upgrade the function of peptides. We developed a new mode for catalytic activation of amino acid Schiff bases, serving as a platform for highly congested ...
Yohei Matsumoto, Jun Sawamura, Yumi Murata, T. Nishikata, R. Yazaki, T. Ohshima   +5 more
semanticscholar   +1 more source

Preparative deracemization of unnatural amino acids

Biochemical Society Transactions, 2006
Unnatural amino acids are a growing class of intermediates required for pharmaceuticals, agrochemicals and other industrial products. However, no single method has proven sufficiently versatile to prepare these compounds broadly at scale. To address this need, we have developed a general chemoenzymatic process to prepare enantiomerically pure L- and D ...
Fotheringham, I, Archer, I, Carr, R, Speight, R, Turner, NJ   +4 more
openaire   +3 more sources

Rational Engineering of Bacillus cereus Leucine Dehydrogenase Towards α-keto Acid Reduction for Improving Unnatural Amino Acid Production.

Biotechnology Journal, 2018
Unnatural amino acids (UAAs) play a key role in modern medicinal chemistry such as small molecules and peptide-based drugs with fast-growing markets.
Junping Zhou, Yaling Wang, Jiajie Chen, Meijuan Xu, Tao-wei Yang, Junxian Zheng, Xian Zhang, Z. Rao   +7 more
semanticscholar   +1 more source