Results 31 to 40 of about 1,161,651 (341)
Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis [PDF]
, 2015 The authors acknowledge the EPSRC and Cancer Research UK (CRUK Grant No. C21383/A6950) for funding this research.Recent reports have highlighted the biological activity associated with a sub-family of the tetramic acid class of natural products.
Healy, Alan +4 more
core +1 more source
Antimicrobial Activity of Amino Acid Analogues and Their Derivatives
Proceedings, 2017 Libraries of compounds containing unnatural amino acids or amino acid analogues were prepared from inexpensive substrates using sustainable processes [1–3]. [...]
Dácil Hernández +4 more
doaj +1 more source
Molecules, 2018 A practical synthesis of both enantiomers of unnatural phenylalanine derivatives by using two pseudoenantiomeric phase transfer catalysts is described.
Lei Jin, Shuai Zhao, Xin Chen
doaj +1 more source
Cell Surface Labeling of Escherichia coli via Copper(I)-Catalyzed [3+2] Cycloaddition [PDF]
, 2003 Labeling of the cell surface of Escherichia coli was accomplished by expression of a recombinant outer membrane protein, OmpC, in the presence of the unnatural amino acid azidohomoalanine, which acts as a methionine surrogate.
Link, A. James, Tirrell, David A.
core +1 more source
Protein engineering with unnatural amino acids
Current Opinion in Structural Biology, 2013 Protein engineering has become an extensively used tool in many fields, allowing us to probe protein function, characterize proteins using a range of biophysical techniques, chemically modify proteins and improve protein function for medical and industrial applications.
Zhang, William +2 more
openaire +3 more sources
Synthesis of complex unnatural fluorine-containing amino acids [PDF]
Journal of Fluorine Chemistry, 2020 The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid derivatives have grown, researchers have turned their attention to develop methodology to access complex proteinogenic examples.
William D.G. Brittain +2 more
openaire +3 more sources
Small Unnatural Amino Acid Carried Raman Tag for Molecular Imaging of Genetically Targeted Proteins.
Journal of Physical Chemistry Letters, 2018 Raman has been implemented to image biological systems for decades. However, Raman microscopy along with Raman probes is restricted to image metabolites or a few intracellular organelles so far and lacks genetic specificity for imaging proteins of ...
Jing Zhang +9 more
semanticscholar +1 more source
Chemistry, 2023 The modification of the methyl group of 4′-(p-tolyl)-2,2′:6′,2″-terpyridine produced the novel unnatural amino acid 3-(4-([2,2′:6′,2″-terpyridin]-4′-yl)phenyl)-2-aminopropanoic acid (phet).
Konstantinos Ypsilantis +5 more
doaj +1 more source
Genetic Code Expansion of Vibrio natriegens
Frontiers in Bioengineering and Biotechnology, 2021 Escherichia coli has been considered as the most used model bacteria in the majority of studies for several decades. However, a new, faster chassis for synthetic biology is emerging in the form of the fast-growing gram-negative bacterium Vibrio ...
Eden Ozer, Lital Alfonta
doaj +1 more source
Bioconjugate chemistry, 2018 Selenocysteine (Sec) is a naturally occurring amino acid that is also referred to as the 21st amino acid. Site-specific incorporation of Sec into proteins is attractive, because the reactivity of a selenol group exceeds that of a thiol group and thus ...
Adarshi P. Welegedara +4 more
semanticscholar +1 more source