Results 91 to 100 of about 1,288,650 (300)

Simple Synthesis of Unnatural Amino Acids via Ni/Ag-Electrocatalytic Cross-Coupling [PDF]

A simple protocol is outlined herein for rapid access to enantiopure unnatural amino acids from trivial glutamate and aspartate precursors. The method relies on Ag/Ni-electrocatalytic decarboxylative coupling and can be rapidly conducted in parallel (24 ...
Shambabu Joseph, Madirala, Ravi Kumar , Puthukanoori, Bheema Rao , Paraselli, Philippe N., Bolduc, Michael C., Nicastri, Rajesh, Chebolu, Maximilian D., Palkowitz, Philipp, Neigenfind, Gabriele, Laudadio, Vanna D., Blasczak, Phil S., Baran   +10 more
core   +3 more sources

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Synthesis and analgesic activity of new analogs of FELL tetrapeptide containing D-Phe in the first position

Current Research in Biotechnology
Pain, whether acute or chronic, is one of the most unpleasant experiences. It can have different origins and long-term effects on the body starting from the trivial once such as physical discomfort, accompanying by emotional distress and going to the ...
Boryana Borisova, Hristina Nocheva, Ivan Iliev, Marie Laronze-Cochard, Stéphane Gérard, Stoyko Petrin, Dancho Danalev   +6 more
doaj   +1 more source

UNNATURAL AMINO ACIDS (UAA’S): A TRENDY SCAFFOLD FOR PHARMACEUTICAL RESEARCH

, 2019
Unnatural amino acids synthesis is a region of research that has gained a lot of interest in modern years. The accessibility of different synthetic routes for new unnatural amino acid derivatives and related compounds will be a critical point in the ...
Bisht, Ajay Singh, Juyal, Divya
core   +1 more source

Chemically Fuelled Deracemization of Amino Acids [PDF]

, 2022
openSystems that work out-of-equilibrium are common in nature, living organisms are the most striking example of that. Chemists are trying to mimic living organisms because of the multitude of properties that might be implemented in synthetic systems ...
DEL VECCHIO, ALICE
core  

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Mild and effective N-phthaloylation of amino acids

, 2004
In the present work various free amino acids, including tryptophan and tyrosine, were effectively N-phthaloylated under reduced pressure and at lower temperature.
Liu, Z, 曾庆乐, Zeng, Q, Li, B, Wang, F   +4 more
core  

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Optical control of protein phosphatase function

Nature Communications, 2019
Protein phosphatases play an essential role in signal transduction, but are understudied due to the difficulties in detecting phosphate removal and the lack of good inhibitors.
Taylor M. Courtney, Alexander Deiters
doaj   +1 more source