Results 141 to 150 of about 33,743 (304)

Computational investigation of the effect of BODIPY labelling on peptide-membrane interaction

Scientific Reports
Optical monitoring of peptide binding to live cells is hampered by the abundance of naturally occurring fluorophores such as tryptophan. Unnatural amino acids incorporating synthetic fluorophores such as BODIPY overcome these optical limitations.
Dominique de Jong-Hoogland, Jacob Ulmschneider, Martin Ulmschneider   +2 more
doaj   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis. [PDF]

Org Process Res Dev, 2021
Faraggi TM, Rouget-Virbel C, Rincón JA, Barberis M, Mateos C, García-Cerrada S, Agejas J, de Frutos O, MacMillan DWC.   +8 more
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Development of mammalian cell logic gates controlled by unnatural amino acids. [PDF]

Cell Rep Methods, 2021
Mills EM, Barlow VL, Jones AT, Tsai YH.
europepmc   +1 more source

Unnatural Amino Acids [PDF]

Chemical & Engineering News Archive, 2014
openaire   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Stereoselective synthesis towards unnatural proline based amino acids

ARKIVOC, 2016
Sifiso S.Makhathini, Sukant K. Das, Thishana Singh, Per I. Arvidsson, Hendrik G. Kruger, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +7 more
doaj   +1 more source

Reagentless electrochemical biosensors through incorporation of unnatural amino acids on the protein structure. [PDF]

Biosens Bioelectron, 2022
Zeynaloo E, Zahran EM, Yang YP, Dikici E, Head T, Bachas LG, Daunert S.   +6 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source