Results 141 to 150 of about 1,288,650 (300)

Development of mammalian cell logic gates controlled by unnatural amino acids. [PDF]

Cell Rep Methods, 2021
Mills EM, Barlow VL, Jones AT, Tsai YH.
europepmc   +1 more source

Photoredox-Catalyzed Difunctionalization of Unsaturated Carbon Compounds with CO2 for the Synthesis of Unnatural Amino Acids

, 2021
Unnatural amino acids have a special function not seen in natural amino acids. Therefore, Unnatural amino acids are introduced into peptides and proteins and widely used as important monomers in drug development and protein processing.
Hyungwoo Hahm
core  

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Reagentless electrochemical biosensors through incorporation of unnatural amino acids on the protein structure. [PDF]

Biosens Bioelectron, 2022
Zeynaloo E, Zahran EM, Yang YP, Dikici E, Head T, Bachas LG, Daunert S.   +6 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents. [PDF]

Cells, 2022
Salehi D, Mozaffari S, Zoghebi K, Lohan S, Mandal D, Tiwari RK, Parang K.   +6 more
europepmc   +1 more source

Unnatural Amino Acids [PDF]

Chemical & Engineering News Archive, 2014
openaire   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Synthesis of 2-amino alcohols and unnatural amino acids from serine

ARKIVOC, 2003
Victoria Magrioti, Georgia Antonopoulou, Evlambia Pantoleon, George Kokotos   +3 more
doaj   +1 more source

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome [PDF]

, 2010
The in vivo, genetically programmed incorporation of designer amino acids allows the properties of proteins to be tailored with molecular precision. The Methanococcus jannaschii tyrosyl-transfer-RNA synthetase–tRNA_(CUA) (MjTyrRS–tRNA_(CUA)) and the ...
Garcia-Alai, Maria, Neumann, Heinz, Davis, Lloyd, Wang, Kaihang, Chin, Jason W.   +4 more
core