Results 181 to 190 of about 33,743 (304)

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Accurate structure prediction of cyclic peptides containing unnatural amino acids using HighFold3. [PDF]

Brief Bioinform
Cao S, Zhu C, Mao Q, Guo J, Zhu N, Duan H.   +5 more
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Unnatural Amino Acids: Strategies, Designs, and Applications in Medicinal Chemistry and Drug Discovery. [PDF]

J Med Chem
Sharma KK, Sharma K, Rao K, Sharma A, Rathod GK, Aaghaz S, Sehra N, Parmar R, VanVeller B, Jain R.   +9 more
europepmc   +1 more source

Probing the Molecular Basis of Protein Function through Chemistry [PDF]

, 2006
Adams, Aharoni, Bang, Behrendt, Bieri, Bordignon, Brune, Cashin, Chen, Dawson, Deechongkit, Dong, El-Andaloussi, Fan, Fernandez-Carneado, Fu, Gammeren, Hodges, Holmgren, Holmgren, Jessani, Keppler, Lummis, Mayville, Muir, Orner, Piatesi, Pick, Plante, Rak, Salvatella, Schiene-Fischer, Schofield, Shin, Speers, Vivero-Pol, Werz, Winssinger, Wright   +38 more
core   +3 more sources

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Isoform-Selective PAD2/PAD4 Substrates with Unnatural Amino Acids Enable Cellular Peptidylarginine Deiminase Activity Profiling and Reveal Vimentin Citrullination Effects in Macrophages. [PDF]

Biochemistry
Gorzeń O, Mikołajczyk-Martinez A, Mamun AA, Horbach N, Severynovska O, Bereta G, Bielecka E, Mydel P, Drąg M, Kantyka T, Poręba M.   +10 more
europepmc   +1 more source

Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time. [PDF]

ACS Chem Biol, 2020
Zerfas BL, Coleman RA, Salazar-Chaparro AF, Macatangay NJ, Trader DJ.   +4 more
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

An amphiphilic peptide with unnatural amino acids as an alignment medium for RDC measurements. [PDF]

Magn Reson Lett
Wang Y, Yin H, Yang Y, Li ZH, Li GW, Lei X.   +5 more
europepmc   +1 more source