Results 101 to 110 of about 176 (153)
S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea
The FEBS Journal, EarlyView.S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels +7 more
wiley +1 more source
The FEBS Journal, EarlyView.Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff +2 more
wiley +1 more source
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source
Methods to Study Mitochondrial Metabolism and Homeostasis in Fission Yeast
Yeast, EarlyView.
Ferran Gómez‐Armengol +2 more
wiley +1 more source
The FEBS Journal, EarlyView.Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet +6 more
wiley +1 more source
Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding
The FEBS Journal, EarlyView.Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh +7 more
wiley +1 more source
Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
The FEBS Journal, EarlyView.Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley +1 more source
SIB1‐SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana
Journal of Integrative Plant Biology, EarlyView.SEC23A mediates membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus and interacts with the immunity protein SIGMA FACTOR‐BINDING PROTEIN1 in Arabidopsis. Under stress, both proteins relocate from the ER to chloroplasts, suppressing photosynthesis genes and enhancing defense genes.
Jialin Peng +7 more
wiley +1 more source