Results 51 to 60 of about 2,350 (139)

The Neural Correlates of Consciousness: A Spectral Exponent Approach to Diagnosing Disorders of Consciousness

Brain Sciences
Background/Objectives: Disorder of consciousness (DoC) poses diagnostic challenges due to behavioral assessment limitations. This study evaluates the spectral exponent (SE)—a neurophysiological biomarker quantifying the decay slope of ...
Ying Zhao, Anqi Wang, Weiqiao Zhao, Nantu Hu, Steven Laureys, Haibo Di   +5 more
doaj   +1 more source

Seizure relapse in new onset epilepsy: It is not always drug resistance

Epilepsia, EarlyView.
Abstract Objective Seizure recurrence in new onset epilepsy (NOE) can result from various factors. Although drug ineffectiveness is frequently investigated, other causes—such as nonadherence, inadequate treatment, nonepileptic events (e.g., functional/dissociative), or acute symptomatic seizures—also impact patient outcomes.
Cecilia Catania, Eric Menetre, Aikaterini Fitsiori, Felix Tobias Kurz, Gabriela Moreno Legast, Serge Vulliemoz, Mathieu Genoud, Pierre Mégevand, Roland Wiest, Fabienne Picard, Sandor Beniczky, Margitta Seeck   +11 more
wiley   +1 more source

Advances in the neurorehabilitation of severe disorder of consciousness

Annali dell'Istituto Superiore di Sanità, 2014
Introduction. The paper describes the evolution of knowledge concerning severe brain injury which determines the Vegetative State/Unresponsive Wakefulness Syndrome. Background. The term Vegetative State was proposed by Jennet and Plum in 1972.
Giuliano Dolce, Lucia Francesca Lucca, Francesco Riganello, Francesco Arcuri, Maria Quintieri, Maria Daniela Cortese, Loris Pignolo   +6 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Homeostatic plasticity in patients with disorders of consciousness detected by combined stimulation: a study protocol

Frontiers in Neurology
BackgroundNon-invasive neuromodulation (NIN) techniques have been widely utilized in treating patients with disorders of consciousness (DoC), but their therapeutic effects have been inconsistent.
Jingwen Wang, Jingwen Wang, Fangfang Shou, Qiuyi Yu, Xulan Lu, Yuwen Wan, Yuwen Wan, Wangshan Huang, Nantu Hu, Zhenyi Jin, Xinru Shan, Steven Laureys, Steven Laureys, Haibo Di   +13 more
doaj   +1 more source

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, EarlyView.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

Exploring end-of-life decision-making in China for disorders of consciousness

Annals of Medicine
Objectives We aim to investigate the ethical attitudes of the Chinese population toward withdrawal of life-sustaining treatment (WLST) in disorders of consciousness (DoC) patients.Methods A self-administered questionnaire concerning WLST was distributed ...
Meiqi Li, Benedetta Cecconi, Olivia Gosseries, Lijuan Cheng, Yifan Yan, Yan Chen, Yan Li, Steven Laureys, Haibo Di   +8 more
doaj   +1 more source

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, Volume 11, Issue 3, Page 847-858, June 2026.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Clinical and Genetic Characterization of Inherited NPRL3 Splice Variants in Two Patients With Epilepsy

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
This study identifies two novel inherited NPRL3 splice variants in Chinese pediatric patients with focal epilepsy, revealing significant genetic heterogeneity, incomplete penetrance, and phenotypic variability that underscores the importance of tailored antiepileptic management.
Shouxing Wang, Jihua Wu, Conglei Song, Yuanzhi He, Zhongli Zhao, Bin Yang   +5 more
wiley   +1 more source

Perception of diagnosis by family caregivers in severe brain injury patients in China

BMC Palliative Care
Objectives Surrogate decision-making by family caregivers for patients with severe brain injury is influenced by the availability and understanding of relevant information and expectations for future rehabilitation. We aimed to compare the consistency of
Yifan Yan, Meiqi Li, Jitka Annen, Wangshan Huang, Tiantian Cai, Xueying Wang, Xiaohua Hu, Steven Laureys, Haibo Di   +8 more
doaj   +1 more source