Results 71 to 80 of about 2,350 (139)

Measures of metabolism and complexity in the brain of patients with disorders of consciousness

NeuroImage: Clinical, 2017
Background: Making an accurate diagnosis in patients with disorders of consciousness remains challenging. 18F-fluorodeoxyglucose (FDG)–PET has been validated as a diagnostic tool in this population, and allows identifying unresponsive patients with a ...
Olivier Bodart, Olivia Gosseries, Sarah Wannez, Aurore Thibaut, Jitka Annen, Melanie Boly, Mario Rosanova, Adenauer G. Casali, Silvia Casarotto, Giulio Tononi, Marcello Massimini, Steven Laureys   +11 more
doaj   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Behavioral and electrophysiological effects of network-based frontoparietal tDCS in patients with severe brain injury: A randomized controlled trial

NeuroImage: Clinical, 2020
Background: Transcranial direct current stimulation (tDCS) may promote the recovery of severely brain-injured patients with disorders of consciousness (DOC).
Géraldine Martens, Eleni Kroupi, Yelena Bodien, Gianluca Frasso, Jitka Annen, Helena Cassol, Alice Barra, Charlotte Martial, Olivia Gosseries, Nicolas Lejeune, Aureli Soria-Frisch, Giulio Ruffini, Steven Laureys, Aurore Thibaut   +13 more
doaj   +1 more source

Global White Matter Damage in Focal Brainstem Injury Patients With Disorders of Consciousness: A Diffusion Tensor Tractography Study

European Journal of Neurology, Volume 33, Issue 1, January 2026.
ABSTRACT Background Disorders of consciousness (DoC) pose significant challenges in clinical diagnosis and treatment. This study aims to investigate the relationship between consciousness levels and the brainstem‐cortical white matter tracts in DoC patients resulting from focal brainstem injury using diffusion tensor imaging (DTI).
Miao Wang, Qiheng He, Sipeng Zhu, Tianqing Cao, Nan Wang, Yitong Jia, Hongbin Wu, Jianfeng Liang, Hongchuan Niu, Zongsheng Xu, Zaixu Cui, Yi Yang, Jizong Zhao   +12 more
wiley   +1 more source

Pancreatic Encephalopathy: A Rare but Critical Complication of Acute Pancreatitis—A Case Report and Literature Review

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
Pancreatic encephalopathy (PE) is a rare but severe neurological complication of acute pancreatitis, characterized by cerebral edema and disruption of the blood–brain barrier due to systemic inflammation and the release of pancreatic enzymes. The pathophysiology involves a complex interplay of inflammatory cytokines and oxidative stress, leading to ...
Edith Joie Jewel M. Paras, James Ibn Aristotle B. Lingad, Jose Emmanuel M. Palo, Lipi Buch   +3 more
wiley   +1 more source

A practical guide to the updated seizure classification 2025

Epileptic Disorders, Volume 27, Issue 6, Page 1087-1104, December 2025.
Abstract This paper provides a practical guide to applying the updated seizure classification in clinical settings. The updated classification, published by the International League Against Epilepsy in 2025, builds on the operational classification introduced in 2017.
Sándor Beniczky, Eugen Trinka, Elaine Wirrell, Mamta Bhushan Singh, Hal Blumenfeld, Alicia Bogacz Fressola, Fernando Cendes, Dana Craiu, Birgit Frauscher, Floor E. Jansen, Philippe Kahane, Veena Kander, Nirmeen Kishk, Ching Soong Khoo, Angelica Lizcano, Luca De Palma, Philippe Ryvlin, Nicola Specchio, Michael R. Sperling, William Tatum, Elza Márcia Yacubian, Jo Wilmshurst, J. Helen Cross   +22 more
wiley   +1 more source

Symptomatic treatment of unresponsive wakefulness syndrome with transcranially focused extracorporeal shock waves

NeuroRehabilitation: An International, Interdisciplinary Journal, 2014
Objective: Can stimulation of nerve growth factors by focused transcranial extracorporeal shock wave therapy (TESWT) be made effective for persons within unresponsive wakefulness syndrome (apallic syndrome)? Design: Between eight and ...
H, Lohse-Busch, U, Reime, R, Falland
openaire   +3 more sources

Cerebral Neurovascular Networks May Serve as Potential Targets for Identifying Disorders of Consciousness: A Synchronous Electroencephalography and Functional Near‐Infrared Spectroscopy Study

MedComm, Volume 6, Issue 12, December 2025.
Simultaneous EEG‐fNIRS recorded resting‐state activity in DoC patients. Neurovascular coupling analysis revealed elevated EEG_beta and fNIRS_HbO connectivity in PMC and Broca's regions, distinguishing MCS from UWS with high accuracy (AUC = 0.879). EEG‐fNIRS multimodal integration supports bedside monitoring.
Nan Wang, Juanning Si, Yifang He, Jiuxiang Song, Xiaoke Chai, Dongsheng Liu, Jingqi Li, Tan Zhang, Tianqing Cao, Qiheng He, Sipeng Zhu, Yitong Jia, Wenbin Ma, Yi Yang, Jizong Zhao   +14 more
wiley   +1 more source

Heart Rate Variability Response to Therapist‐Selected Music as a Diagnostic Biomarker for Disorders of Consciousness

Sensory Neuroscience, Volume 1, Issue 3, December 2025.
Music modulates autonomic pathways to alter heart rate variability (HRV), with therapist‐selected music (TSM) showing the strongest association with consciousness levels in patients with disorders of consciousness (DOC). ABSTRACT Music, as an auditory stimulus, has long been recognized for its ability to evoke heart rate variability (HRV) responses. In
Jiajia Kang, Haidi Wu, Ling Wang, Xiaodan Tan, Yun Wen, Feng Yang, Qiuyou Xie, Chang'an A. Zhan   +7 more
wiley   +1 more source

The Comorbidities Coma Scale (CoCoS): Psychometric Properties and Clinical Usefulness in Patients With Disorders of Consciousness

Frontiers in Neurology, 2019
Although comorbidities have a well-known impact on the functional recovery of patients with disorders of consciousness, including coma, vegetative state (VS), and minimally conscious state (MCS), a specific tool for their assessment in this challenging ...
Francesca Pistoia, Antonio Carolei, Yelena G. Bodien, Yelena G. Bodien, Sheldon Greenfield, Sherrie Kaplan, Simona Sacco, Caterina Pistarini, Alfonsina Casalena, Antonio De Tanti, Benedetta Cazzulani, Gianluca Bellaviti, Marco Sarà, Joseph Giacino   +13 more
doaj   +1 more source