Results 41 to 50 of about 339,664 (287)

Diagnostic tools for 3D unstructured oceanographic data

, 2007
Most ocean models in current use are built upon structured meshes. It follows that most existing tools for extracting diagnostic quantities (volume and surface integrals, for example) from ocean model output are constructed using techniques and software ...
Atkinson, C.J. Cotter, Danilov, Ford, Fringer, G.J. Gorman, Ham, Jones, Legrand, Oliphant, Pain, Pain, Ramachandran   +12 more
core   +1 more source

Developing a patient measure of safety (PMOS) [PDF]

, 2013
Background: Tools that proactively identify factors that contribute to accidents have been developed within high-risk industries. Although patients provide feedback on their experience of care in hospitals, there is no existing measure which asks ...
Ashley, Baillie, Blenkinsopp, Bloor, Castle, DeVellis, Dougall, Egberts, Fitzpatrick, Giles, Goldstein, Hinchcliff, Hinkin, Hollway, Jenkinson, Lawton, Neuendorf, Pettersen, Schwappach, Sitzia, Stone, van Someren, Ward, Ward, Watt, Weingart, Weingart, Weissman, Williams   +28 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Composite Barrier Function Sliding Mode Control Method Based on an Extended State Observer for the Path Tracking of Unmanned Articulated Vehicles

Drones
Unmanned articulated vehicles play a crucial role in the intelligent mine system and have been extensively investigated and implemented in the fields of mine transportation, agriculture and forestry construction.
Kanghua Zhang, Xiaochao Gu, Nan Wang, Jialu Cao, Jixin Wang, Shaokai Zhang, Xiang Li   +6 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Formal and informal social care in people with Rheumatic and Musculoskeletal diseases: a cross‐sectional multicentre survey

Arthritis Care &Research, Accepted Article.
Introduction Rheumatic and musculoskeletal diseases(RMDs) are leading causes of physical disability, necessitating support with activities of daily living(ADLs). This study describes social care received by patients with RMDs in two disperate regions of England: Salford(urban) and Norfolk(rural).
Mehreen Somro, Karen Durrant, William G Dixon, John McBeth, Alex MacGregor, Max Yates, Jenny H Humphreys   +6 more
wiley   +1 more source

Factors Affecting The Usability Of Unstructured Big Data

JISR on Computing, 2020
Big data is a valuable asset for organisation as it analyses and help to understand the customers, changes within their business environment, market analysis and future trends.
Joshua Devadason, Rehan Akbar
doaj   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Autonomous navigation of quadrupeds using coverage path planning with morphological skeleton maps

Frontiers in Robotics and AI
This article proposes a novel method of coverage path planning for the purpose of scanning an unstructured environment autonomously. The method uses the morphological skeleton of a prior 2D navigation map via SLAM to generate a sequence of points of ...
Alexander James Becoy, Alexander James Becoy, Kseniia Khomenko, Luka Peternel, Raj Thilak Rajan   +4 more
doaj   +1 more source

Development of mobile sensor terminals “Portable Go” for navigation in informationally structured and unstructured environments

ROBOMECH Journal, 2019
This paper proposes a navigation system of a personal mobility robot in informationally structured and unstructured environments. First, we introduce a group of robots named Portable Go, which are equipped with laser range finders, gyros, and omni ...
Yuuta Watanabe, Akio Shigekane, Kohei Matsumoto, Akihiro Kawamura, Ryo Kurazume   +4 more
doaj   +1 more source