Results 11 to 20 of about 246,994 (340)
Translating the Untranslated Region [PDF]
The Journal of Immunology, 2015 Abstract Gene expression programs undergo constant regulation to quickly adjust to environmental stimuli that alter the physiological status of the cell, like cellular stress or infection. Gene expression is tightly regulated by multilayered regulatory elements acting in both cis and trans.
Ram Savan, Johannes Schwerk
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The Untranslated Regions of mRNAs in Cancer [PDF]
Trends in Cancer, 2019 The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer ...
Andrew C. Hsieh +2 more
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Properties of untranslated regions of the S. cerevisiae genome [PDF]
BMC Genomics, 2009 During evolution selection forces such as changing environments shape the architecture of genomes. The distribution of genes along chromosomes and the length of intragenic regions are basic genomic features known to play a major role in the regulation of gene transcription and translation.In this work we perform the first large scale analysis of the ...
Tamir Tuller +2 more
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Genetic variants in mRNA untranslated regions [PDF]
WIREs RNA, 2018 Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants associated with complex disease risk and regulating quantitative traits, thus exploiting an unprecedented high‐resolution genetic characterization of the human genome. A small fraction (3.7%) of the identified associations is located in untranslated regions (UTRs), and the
Steri M, Idda ML, Whalen MB, Orru' V
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Regulatory 3′ Untranslated Regions of Bacterial mRNAs [PDF]
Frontiers in Microbiology, 2017 The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5'regions; however, 3'UTRs have recently emerged as a new class of post-transcriptional regulatory elements.
Yi-Cheng Sun, Gai-Xian Ren, Xiaopeng Guo
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The 5′ and 3′ Untranslated Regions of the Flaviviral Genome [PDF]
Viruses, 2017 Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped RNA genome consists of a single open reading frame (ORF), and is flanked by 5′ and 3′ untranslated regions (UTR).
Wy Ng +4 more
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Dom34 Rescues Ribosomes in 3′ Untranslated Regions [PDF]
Cell, 2014 Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here, we extend ribosome profiling methodology to reveal a high-resolution molecular characterization
Rachel Green, Nicholas R. Guydosh
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Untranslated regions of mRNAs.
Genome biology, 2002 Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, upstream initiation codons and open reading frames, internal ribosome entry sites and various cis-acting elements that are bound by RNA-binding ...
MIGNONE, Flavio +3 more
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Sequence conservation in the 3′-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs [PDF]
, 1987 The C-terminal protein-coding and the entire 3′-untranslated regions of a cDNA corresponding to human neurone-specific enolase mRNA have been sequenced.
Allsopp, M.T.E.P. +3 more
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Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1. [PDF]
PLoS ONE, 2014 Eukaryotic cells control their growth and morphogenesis to maintain integrity and viability. Free-living cells are further challenged by their direct interaction with the environment and in many cases maintain a resilient cell wall to stay alive under ...
Antony G Wanless, Yuan Lin, Eric L Weiss
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