Translating the Untranslated Region [PDF]
The Journal of Immunology, 2015 Abstract Gene expression programs undergo constant regulation to quickly adjust to environmental stimuli that alter the physiological status of the cell, like cellular stress or infection. Gene expression is tightly regulated by multilayered regulatory elements acting in both cis and trans.
Johannes, Schwerk, Ram, Savan
openaire +2 more sources
Characterization of Single Nucleotide Variants of OPN3 Gene in Melanocytic Nevi and Melanoma
JID Innovations, 2021 In this study, we examined single nucleotide variants (SNVs) of the OPN3 gene in malignant melanoma and melanocytic nevi. A total of 20 variants of SNVs were detected.
Wei Zhang +5 more
doaj +1 more source
The androgen receptor messenger RNA: what do we know?
RNA Biology, 2022 The Androgen Receptor (AR), transcriptionally activated by its ligands, testosterone and dihydrotestosterone (DHT), is widely expressed in cells and tissues, influencing normal biology and disease states. The protein product of the AR gene is involved in
Eviania Likos +3 more
doaj +1 more source
The Roles of the 5′ and 3′ Untranslated Regions in Human Astrovirus Replication
Viruses, 2023 Astroviruses are small nonenveloped single-stranded RNA viruses with a positive sense genome. They are known to cause gastrointestinal disease in a broad spectrum of species.
Nicole Wildi, Torsten Seuberlich
doaj +1 more source
Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1. [PDF]
PLoS ONE, 2014 Eukaryotic cells control their growth and morphogenesis to maintain integrity and viability. Free-living cells are further challenged by their direct interaction with the environment and in many cases maintain a resilient cell wall to stay alive under ...
Antony G Wanless, Yuan Lin, Eric L Weiss
doaj +1 more source
Genetic variants in mRNA untranslated regions [PDF]
WIREs RNA, 2018 Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants associated with complex disease risk and regulating quantitative traits, thus exploiting an unprecedented high‐resolution genetic characterization of the human genome. A small fraction (3.7%) of the identified associations is located in untranslated regions (UTRs), and the
Steri M, Idda ML, Whalen MB, Orru' V
openaire +3 more sources
Selective translation of the measles virus nucleocapsid mRNA by La protein
Frontiers in Microbiology, 2011 Measles, caused by measles virus (MeV) infection, is the leading cause of death in children because of secondary infections attributable to MeV-induced immune suppression.
Yoshihisa eInoue +5 more
doaj +1 more source
A novel interaction between the 5' untranslated region of the Chikungunya virus genome and Musashi RNA binding protein is essential for efficient virus genome replication. [PDF]
Nucleic Acids ResSun K +6 more
europepmc +3 more sources
Regulatory 3′ Untranslated Regions of Bacterial mRNAs [PDF]
Frontiers in Microbiology, 2017 The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5'regions; however, 3'UTRs have recently emerged as a new class of post-transcriptional regulatory elements.
Ren, Gai-Xian +2 more
openaire +3 more sources
Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]
PLoS ONE, 2011 In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi +4 more
doaj +1 more source