Results 21 to 30 of about 162,571 (289)
Viruses, 2019 The 5′ untranslated region (UTR) of the RNA genomes of enteroviruses possesses an internal ribosome entry site (IRES) that directs translation of the mRNA by binding to ribosomes.
Yuki Furuse +3 more
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Dom34 Rescues Ribosomes in 3′ Untranslated Regions [PDF]
Cell, 2014 Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here, we extend ribosome profiling methodology to reveal a high-resolution molecular characterization
Guydosh, Nicholas R., Green, Rachel
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Tumor Biology, 2017 X-linked inhibitor of apoptosis protein functions as an intrinsic regulator of apoptosis by inhibition of caspase activity and possesses a pivotal role in human cancer development and progression.
Wen-Yong Wu +4 more
doaj +1 more source
The RNA Architecture of the SARS-CoV-2 3′-Untranslated Region
Viruses, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3′ untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication ...
Junxing Zhao +4 more
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The Untranslated Regions of mRNAs in Cancer [PDF]
Trends in Cancer, 2019 The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer ...
Samantha L, Schuster, Andrew C, Hsieh
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Novel Dengue Virus Type 1 from Travelers to Yap State, Micronesia
Emerging Infectious Diseases, 2006 Dengue virus type 1 (DENV-1), which was responsible for the dengue fever outbreak in Yap State, Micronesia, in 2004, was isolated from serum samples of 4 dengue patients in Japan. Genome sequencing demonstrated that this virus belonged to genotype IV and
Yoko Nukui +6 more
doaj +1 more source
Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
Cell Reports, 2020 Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators.
Tanner Stokes +13 more
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Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2
Virulence, 2022 It was noticed that the mortality rate of SARS-CoV-2 infection experienced a significant declination in the early stage of the epidemic. We suspect that the sharp deterioration of virus toxicity is related to the deletion of the untranslated region (UTR)
Zhaobin Xu +3 more
doaj +1 more source
Journal of Lipid Research, 2009 The 3′untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization induced by berberine (BBR).
Hai Li +7 more
doaj +1 more source
Expression of distinct RNAs from 3′ untranslated regions [PDF]
Nucleic Acids Research, 2010 The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3'UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
T. Mercer +12 more
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