Results 211 to 220 of about 25,321,967 (307)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

RETRACTION: Up-regulation of KISS1 as a Novel Target of Let-7i in Melanoma Serves as a Potential Suppressor of Migration and Proliferation In Vitro. [PDF]

J Cell Mol Med
europepmc   +1 more source

Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in a <i>Drosophila</i> model of fragile X syndrome. [PDF]

Proc Natl Acad Sci U S A
Colt M, Gordon A, Peng YJ, Wu Y, Martin K, Chang KT.   +5 more
europepmc   +1 more source

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

Proceedings of the National Academy of Sciences of the United States of America, 2015
Wuyang Wang, Qiong Gao, Meimei Yang, Xiao-Li Zhang, Lu Yu, M. Lawas, Xinran Li, Marthe Bryant-Genevier, Noel Southall, J. Marugan, M. Ferrer, Hao-Xing Xu   +11 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress

We have previously shown that most melanoma cell lines are insensitive to endoplasmic reticulum (ER) stress-induced apoptosis, and this involves activation of the mitogen-activated protein/extracellular signal-regulated kinase (MEK)/ERK Signaling pathway
Margaret Wade (14884769), Keryn Lucas (14884763), Chen Chen Jiang (21131984), Charles E. deBock (14884772), Peter Hersey (441741), Xu Dong Zhang (21134519), Kelly Kiejda (21132314), Rick F. Thorne (11680261), John Allen (200689)   +8 more
core  

Histone lactylation-mediated up-regulation of IGF2BP2 enhances ferroptosis resistance via Nrf2 in colorectal cancer. [PDF]

Clin Transl Med
Zhu JF, Guo DP, Lv HN, Liang ZY, Song J, Zeng W.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

N6-methyladenosine-mediated up-regulation of ARRB2 regulates intrahepatic cholangiocarcinoma malignant progression and pemigatinib resistance through MAPK and Hippo signaling pathways. [PDF]

Cell Death Dis
Chen H, Wang X, Zhu W, Zheng W, Yang Q, Liang Z, Zhang Y, Li X, Liang J, Chen X, Li H, Ye L, Li H, Yan X, Zhu S, Wang G.   +15 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source