Results 221 to 230 of about 25,321,967 (307)

Positive emotion up-regulation in the wake of a cognitively demanding task: An event-related potential study. [PDF]

Behav Res Ther
Driskill T, Watanabe BK, MacNamara A.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

RETRACTION: Fibronectin Promotes Migration and Invasion of Ovarian Cancer Cells through Up-Regulation of FAK-PI3K/Akt Pathway. [PDF]

Cell Biol Int
europepmc   +1 more source

Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding protein Sam68 in head and neck cancer. [PDF]

Front Microbiol
Cerasuolo A, Pecchillo Cimmino T, Gagliarde S, D'Orsi PCC, Starita N, Amiranda S, Tornesello AL, Dassi L, Bonelli P, Tuccillo FM, Buonaguro FM, Longo F, Perri F, Rega RA, De Cecio R, Ferrara G, Ionna F, Tornesello ML.   +17 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

14-3-3σ up-regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders. [PDF]

Brain Pathol
Marsal-García L, Mena J, Lao CA, Adamuz D, Arnaldo L, Carrato C, Menendez A, Samaniego D, Vilas D, Ispierto L, Planas A, Alvarez R, Pastor P, Beyer K.   +13 more
europepmc   +1 more source

Phosphoinositides: tiny lipids with giant impact on cell regulation.

Physiological Reviews, 2013
T. Balla
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

EXPRESSION OF CONCERN: "Up-Regulation of Gadd45α After Exposure to Metal Nanoparticles: The Role of Hypoxia Inducible Factor 1α". [PDF]

Environ Toxicol
europepmc   +1 more source

NFYA-Mediated TTK Up-Regulation Drives Fast Cell Cycle Progression and Its Inhibition Leads to Mitotic Catastrophe in Triple Negative Breast Cancer. [PDF]

Cancers (Basel)
Liu N, Zhu M, Cai Z, Wang J, Cao W, Shi Q, Wang L, Jiang X, Zhou J, Lin J, Yang W, Gan H, Nie J, Liu Q.   +13 more
europepmc   +1 more source