Results 261 to 270 of about 25,321,967 (307)

Advanced azelaic acid hyalubilosome-loaded microneedles for potent anti-inflammatory, antioxidant, and antimicrobial for Acne treatment by up-regulation of Nrf2/HO-1 signaling pathway. [PDF]

Int J Pharm X
Elhabal SF, Elrefai MFM, Hassan FE, Tolba NS, El Galil RMA, Morsy SAA, Allam S, Emam AM, Wanas H, Azer MS, Ahmed MM, Abdelmoneim HA, Fady M, Hamdan AME.   +13 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

<i>CEBPB</i> Expression in Tumor Cells Drives Immune Evasion in Colorectal Cancer via <i>CTLA4</i> Up-regulation in T Cells. [PDF]

Cancer Commun (Lond)
Yun HJ, Park CH, Yun D, Shin HR, Lee JD, Park C, Kim K, Shim H, Sim H, Kim SM, Kim MJ, Park JW, Ryoo SB, Lim Y, Jeong SY, Park KJ, Kim TY, Kim J, Won JK, Han SW.   +19 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis. [PDF]

Acta Oncol
Fonfara KE, Fredsøe J, Ulhøi B, Borgquist S, Borre M, Sørensen KD.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway. [PDF]

Cell Death Discov
Cai H, Zheng HL, Chen QZ, Song SK, Yang BY, Wang Y, Deng H, Mardan M, Lu ZY, Chen PB, Xu QY, Li B, Jiang LS, Zheng XF, Jiang SD.   +14 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Author Correction: Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma. [PDF]

Commun Biol
Feng Y, Ni Q, Wu N, Xie T, Yun F, Zhang X, Gao L, Gai Y, Li E, Yi X, Xie J, Zhang Q, Yang Z, Sai B, Kuang Y, Zhu Y.   +15 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source