Results 271 to 280 of about 25,321,967 (307)

β-Sitosterol as an Anti-Tumour Active Component of Herba Sarcandrae Inhibits Colorectal Cancer Progression Through Up-Regulation of TBX20. [PDF]

J Cell Mol Med
Yuan H, Feng W, Yang S, Yin H, Ouyang S, Xie H, Tang H, Ou X, Gong X, Yuan J.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Linc00963 up-regulation alleviates postmenopausal osteoporosis through suppression of miR-506-3p. [PDF]

J Orthop Surg Res
Li Q, Zhao J, Yang X, Guo L, Xu Y.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Retraction: Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. [PDF]

Oncotarget
Nwaeburu CC, Bauer N, Zhao Z, Abukiwan A, Gladkich J, Benner A, Herr I.   +6 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Transcriptionally up-regulation of CDKN1A/p21 by TFE3 fusion proteins worsened TFE3-rearranged renal cell carcinoma. [PDF]

Sci Rep
Lu Y, Ma W, Chen Y, Dong X, Pan X, Yang L, Zhou S, Liu N, Li D, Gan W.   +9 more
europepmc   +1 more source

Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport. [PDF]

Gastroenterology
Kesaraju S, Li Y, Xing J, Ghadiri M, Tracy M, Wannemo K, Holder A, Zhao P, Wu Q, Khan MA, Wood S, Durgam S, Kainov J, Rana N, Sidahmed M, Hyoju S, Smith L, Matthews JM, Wu R, Tay S, Khalili-Araghi F, Geisz-Fremy A, Rana M, Oakes SA, Shen L, Weber CR.   +25 more
europepmc   +1 more source

Up-regulation of MSMO1 was associated with poor survival in cervical cancer. [PDF]

Transl Cancer Res
Zou J, Liu S, Long J.
europepmc   +1 more source

NSUN5 Mediates Resistance to Doxorubicin via Up-regulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer. [PDF]

Am J Pathol
Xu Y, Qin C, Zhang M, Wu Q, Li Z, Mo H, Chen C, Zhou A, Li J, Ni W.   +9 more
europepmc   +1 more source