Results 171 to 180 of about 8,024 (201)
UPF1 promotes rapid degradation of m6A-containing RNAs
Cell Reports, 2022 N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m6A-recognizing protein, binds to m6A, it facilitates the destabilization of m6A-containing RNAs (m6A RNAs).
Hongseok Ha +2 more
exaly +3 more sources
Structure-Mediated RNA Decay by UPF1 and G3BP1 [PDF]
Molecular Cell, 2020 Post-transcriptional mechanisms regulate the stability and, hence, expression of coding and noncoding RNAs. Sequence-specific features within the 3' untranslated region (3' UTR) often direct mRNAs for decay. Here, we characterize a genome-wide RNA decay pathway that reduces the half-lives of mRNAs based on overall 3' UTR structure formed by base ...
Veronica F Busa, Anthony K L Leung
exaly +3 more sources
Upf1 Senses 3′UTR Length to Potentiate mRNA Decay [PDF]
Cell, 2010 The selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control process with important consequences for human disease. From initial studies using RNA hairpin-tagged mRNAs for purification of messenger ribonucleoproteins assembled on transcripts with HIV-1 3' untranslated region (3'UTR) sequences, we uncover a two-step ...
J Robert Hogg, Stephen P Goff
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The Upf1 protein restricts EV-A71 viral replication
Microbes and Infection, 2023Enterovirus A71 (EV-A71) is transmitted through the respiratory tract, gastrointestinal system, and fecal-oral routes. The main symptoms caused by EV-A71 are hand, foot, and mouth disease (HFMD) or vesicular sore throat. Upf1 (Up-frameshift protein 1) was reported to degrade mRNA containing early stop codons, known as nonsense-mediated decay (NMD ...
Peng Xu +4 more
openaire +2 more sources
Biochemical Society Transactions, 2008
NMD (nonsense-mediated mRNA decay) is a mechanism that degrades transcripts containing PTCs (premature translation termination codons). NMD is a translation-associated process that is expected to take place throughout the cytoplasm. However, recent studies have indicated that the core NMD factors UPF1 (up-frameshift-1), UPF2 and UPF3 can associate with
Saverio, Brogna +2 more
openaire +2 more sources
NMD (nonsense-mediated mRNA decay) is a mechanism that degrades transcripts containing PTCs (premature translation termination codons). NMD is a translation-associated process that is expected to take place throughout the cytoplasm. However, recent studies have indicated that the core NMD factors UPF1 (up-frameshift-1), UPF2 and UPF3 can associate with
Saverio, Brogna +2 more
openaire +2 more sources
UPF1 involvement in nuclear functions
Biochemical Society Transactions, 2012UPF1 (up-frameshift 1) is a protein conserved in all eukaryotes that is necessary for NMD (nonsense-mediated mRNA decay). UPF1 mainly localizes to the cytoplasm and, via mechanisms that are linked to translation termination but not yet well understood, stimulates rapid destruction of mRNAs carrying a PTC (premature translation termination codon ...
Wazeer, Varsally, Saverio, Brogna
openaire +2 more sources
Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay [PDF]
Cell, 2008 In mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that translation terminates sufficiently upstream of a post-splicing exon junction complex (EJC) during a pioneer round of translation. The subsequent binding of Upf1 to the EJC triggers Upf1 phosphorylation.
Yoon Ki Kim, Nao Hosoda, Lynne E Maquat
exaly +3 more sources
Targeting of viral RNAs by Upf1-mediated RNA decay pathways
Current Opinion in Virology, 2021Viral RNAs are susceptible to co-translational RNA decay pathways mediated by the RNA helicase Upstream frameshift 1 (Upf1). Upf1 is a key component in nonsense-mediated decay (NMD), Staufen1-mediated mRNA decay (SMD), and structure-mediated RNA decay (SRD) pathways, among others.
Jared P May, Anne E Simon
openaire +2 more sources
Biochemical Characterization of Human Upf1 Helicase
2009We present here the biochemical characterization of human Upf1 helicase core (hUpf1c). hUpf1c is overexpressed as a GST fusion protein in Escherichia coli and purified using chromatographic methods. In vitro ATP binding and single-stranded RNA (ssRNA) binding activities are measured using dot-blot technique. Measurement of RNA-dependent ATPase activity
Zhihong, Cheng +2 more
openaire +2 more sources