Results 181 to 190 of about 8,024 (201)

Antioxidant UPF1 attenuates myocardial stunning in isolated rat hearts

International Journal of Cardiology, 2008
Oxidative stress is a crucial pathophysiological mechanism of myocardial ischaemia-reperfusion injury (IRI). We evaluated the cardioprotective effects of a novel glutathione analogue, UPF1 (4-methoxy-L-tyrosinyl-gamma-L-glutamyl-L-cysteinyl-glycine; MW 483.5), on an isolated rat heart model of thirty-minute global ischaemia followed by 90 min of ...
Jaak, Kals, Joel, Starkopf, Mihkel, Zilmer, Tõnis, Pruler, Kristel, Pulges, Monika, Hallaste, Mart, Kals, Andres, Pulges, Ursel, Soomets   +8 more
openaire   +2 more sources

Advances in molecular function of UPF1 in Cancer

Archives of Biochemistry and Biophysics
It is known that more than 10 % of genetic diseases are caused by a mutation in protein-coding mRNA (premature termination codon; PTC). mRNAs with an early stop codon are degraded by the cellular surveillance process known as nonsense-mediated mRNA decay (NMD), which prevents the synthesis of C-terminally truncated proteins.
Temaj, Gazmend, Chichiarelli, Silvia, Telkoparan-Akillilar, Pelin, Saha, Sarmistha, Nuhii, Nexhibe, Hadziselimovic, Rifat, Saso, Luciano   +6 more
openaire   +4 more sources

Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP−Seq)

2017
Recent progress in the technology of transcriptome-wide high-throughput sequencing has revealed that nonsense-mediated mRNA decay (NMD) targets ~10% of physiologic transcripts for the purpose of tuning gene expression in response to various environmental conditions.
Tatsuaki, Kurosaki, Mainul, Hoque, Lynne E, Maquat   +2 more
openaire   +2 more sources

How UPF1 helicase activity facilitates mRNA decay

Biophysical Journal, 2022
Joseph H. Chapman, Keir C. Neuman, J.R. Hogg   +2 more
openaire   +1 more source

Counter-regulation of RNA stability by UPF1 and TDP43

AbstractRNA quality control is crucial for proper regulation of gene expression. Disruption of nonsense mediated mRNA decay (NMD), the primary RNA decay pathway responsible for the degradation of transcripts containing premature termination codons (PTCs), can disrupt development and lead to multiple diseases in humans and other animals.
Nicolas Gomez, Caroline Hsieh, Xingli Li, Megan Dykstra, Jacob Waksmacki, Christopher Altheim, Yoel Bechar, Joseph Klim, Benjamin Zaepfel, Jeffrey Rothstein, Elizabeth EM Tank, Sami J Barmada   +11 more
openaire   +2 more sources

Application of HyperTRIBE to UPF1 in HEK293 cells

The application of HyperTRIBE technology to identify target genes of the RNA-binding protein UPF1 in HEK293 cells. This study includes five RNA-seq samples: two biological replicates of UPF1-ADAR2cd, two biological replicates of mCherry-ADAR2cd, and one GFP sample.
openaire   +1 more source

Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3′UTRs so as to Elicit mRNA Decay

Cell, 2005
Yoon Ki Kim, Luc Furic, Luc DesGroseillers   +2 more
exaly  

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

Cell, 2010
Jens Lykke-Andersen, Guramrit Singh
exaly  

The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma

Nature Medicine, 2014
Rachid Karam, fang su, Yuan Ji
exaly  

The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity

Molecular Cell, 2017
Qing Feng, Sujatha Jagannathan, Robert K Bradley   +2 more
exaly